NU1M_NYCNO
ID NU1M_NYCNO Reviewed; 301 AA.
AC O80003;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
DE Flags: Fragment;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Nyctalus noctula (Noctule bat).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Nyctalus.
OX NCBI_TaxID=51300;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Petit E., Excoffier L., Mayer F.;
RT "No evidence of bottlenecks in the post-glacial recolonization of Europe by
RT the noctule bat (Nyctalus noctula).";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AF065104; AAC28345.1; -; Genomic_DNA.
DR EMBL; AF065108; AAC28349.1; -; Genomic_DNA.
DR EMBL; AF065109; AAC28350.1; -; Genomic_DNA.
DR AlphaFoldDB; O80003; -.
DR SMR; O80003; -.
DR PRIDE; O80003; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN <1..>301
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117439"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT NON_TER 1
FT NON_TER 301
SQ SEQUENCE 301 AA; 33958 MW; B294975131BB0D09 CRC64;
LTTIIPILLA VAFLTLLERK VLGYMQLRKG PNIVGPYGLL QPIADAVKLF IKEPLQPLTS
SLALFIIAPT LALTLALMMW IPLPMPHPLI NMNLSILFML ALSSLAVYAI LWSGWASNSK
YALIGALRAV AQTISYEVTL AIIILSILLM NGSFTLSTLI TTQEYTWLIM PSWPLAMMWF
ISTIAETNRA PFDLTEGESE LVSGFNVEYA GGPFALFFLA EYANIIMMNA LTIILFLGAY
NNSTFPEMYT ANFMLKALLF TTFFLWIRAS YPRFRYDQLM HLLWKNFLPL TLVMCMWHVT
L
