NU1M_OENBE
ID NU1M_OENBE Reviewed; 331 AA.
AC P31839;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1; Synonyms=NAD1;
OS Oenothera berteroana (Bertero's evening primrose).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Oenothera.
OX NCBI_TaxID=3950;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RX PubMed=1850322; DOI=10.1016/0092-8674(91)90465-b;
RA Wissinger B., Schuster W., Brennicke A.;
RT "Trans splicing in Oenothera mitochondria: nad1 mRNAs are edited in exon
RT and trans-splicing group II intron sequences.";
RL Cell 65:473-482(1991).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=7 {ECO:0000269|PubMed:1850322}, 95
CC {ECO:0000269|PubMed:1850322}, 109 {ECO:0000269|PubMed:1850322}, 129
CC {ECO:0000269|PubMed:1850322}, 132 {ECO:0000269|PubMed:1850322}, 170
CC {ECO:0000269|PubMed:1850322}, 173 {ECO:0000269|PubMed:1850322}, 185
CC {ECO:0000269|PubMed:1850322}, 200 {ECO:0000269|PubMed:1850322}, 218
CC {ECO:0000269|PubMed:1850322}, 231 {ECO:0000269|PubMed:1850322}, 251
CC {ECO:0000269|PubMed:1850322}, 253 {ECO:0000269|PubMed:1850322}, 254
CC {ECO:0000269|PubMed:1850322}, 258 {ECO:0000269|PubMed:1850322}, 281
CC {ECO:0000269|PubMed:1850322}, 306 {ECO:0000269|PubMed:1850322}, 316
CC {ECO:0000269|PubMed:1850322}, 319 {ECO:0000269|PubMed:1850322};
CC -!- MISCELLANEOUS: Exons b and c and d and e are cis-spliced, while trans-
CC splicing reactions are required to link exons a and b and c and d.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
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DR EMBL; M63033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P31839; -.
DR SMR; P31839; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; RNA editing; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..331
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117441"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 331 AA; 36667 MW; 26764C0FF001A82A CRC64;
MNRKSKMYIA VPAEILGIIL PLLLGVAFLV LAERKVMAFV QRRKGPDVVG SFGLLQPLAD
GLKLILKEPI SPSSANFSLF RMAPVATFML SLVAWAVVPF DYGMVLSDLN IGLLYLFAIS
SLGVYGIIIA GWSSNSKYAF LGALRSAAQM VSYEVSIGLI LITVLICVGS CNLSEIVMAQ
KQIWFGIPLF PVLVMFFISC LAETNRAPFD LPEAEAELVA GYNVEYSSMG FALFFLGEYA
NMILMSGLCT LLFLGGWLPI LDLPIFKKIP GSIWFSIKVI FFLFLYIWVR AAFPRYRYDQ
LMGLGWKVFL PLSLAWVVSV SGVLVTFQWL P
