ID   NU1M_PARTE              Reviewed;         261 AA.
AC   P05513;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1; Synonyms=NDH1;
OS   Paramecium tetraurelia.
OG   Mitochondrion.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Stock 51;
RX   PubMed=2308823; DOI=10.1093/nar/18.1.173;
RA   Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E.,
RA   Cummings D.J.;
RT   "Nucleotide sequence of the mitochondrial genome of Paramecium.";
RL   Nucleic Acids Res. 18:173-180(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-166.
RX   PubMed=3023187; DOI=10.1016/0378-1119(86)90188-5;
RA   Pritchard A.E., Seilhamer J.J., Cummings D.J.;
RT   "Paramecium mitochondrial DNA sequences and RNA transcripts for cytochrome
RT   oxidase subunit I, URF1, and three ORFs adjacent to the replication
RT   origin.";
RL   Gene 44:243-253(1986).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X15917; CAA34031.1; -; Genomic_DNA.
DR   EMBL; M15281; AAA79252.1; -; Genomic_DNA.
DR   PIR; S07752; S07752.
DR   AlphaFoldDB; P05513; -.
DR   SMR; P05513; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..261
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117447"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   261 AA;  29781 MW;  E5212E1582DE2E4E CRC64;
     MLIYSIVLML VVTLIIASIT LLERKLLSLV QRRVGPNFVG YKGRLQYLAD ALKLFLKGVA
     IPSGANSFFF VAMPSLAGAV CYTFWMNSIW GPSLSMFDVE YNIVYASLLS ILFGLCVMLT
     GYFSKNKYSV MAGLRAAILM LNLEIFLGIV FLNVCFLVES FSFAAFAVYQ EIFWLIFLFF
     FLLSNILLVF LLEVNRTPFD LAEAESELVT GYTTEYGGFY FALFYLGEYF HLFFFSCLIS
     VVFFGSWELL KPFLFLHNYT V