ID   NU1M_PATPE              Reviewed;         326 AA.
AC   P23650; Q37410;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1;
OS   Patiria pectinifera (Starfish) (Asterina pectinifera).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Valvatacea; Valvatida; Asterinidae; Patiria.
OX   NCBI_TaxID=7594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RX   PubMed=7672576; DOI=10.1093/genetics/140.3.1047;
RA   Asakawa S., Himeno H., Miura K., Watanabe K.;
RT   "Nucleotide sequence and gene organization of the starfish Asterina
RT   pectinifera mitochondrial genome.";
RL   Genetics 140:1047-1060(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-129.
RX   PubMed=2766382; DOI=10.1007/bf00435506;
RA   Jacobs H.T., Asakawa S., Araki T., Miura K., Smith M.J., Watanabe K.;
RT   "Conserved tRNA gene cluster in starfish mitochondrial DNA.";
RL   Curr. Genet. 15:193-206(1989).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; D16387; BAA03879.2; -; Genomic_DNA.
DR   EMBL; X16886; CAA34766.1; ALT_SEQ; Genomic_DNA.
DR   PIR; S70596; S70596.
DR   RefSeq; NP_008167.2; NC_001627.1.
DR   AlphaFoldDB; P23650; -.
DR   SMR; P23650; -.
DR   GeneID; 807817; -.
DR   CTD; 4535; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..326
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117350"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  36124 MW;  1C202307950B5710 CRC64;
     MDWFVFFVNS ILFIVPVLLA VALLTLVERK VLGYMQLRKG PNIVGPFGLL QPIADGFKLL
     IKETLKPSNA SPYLFFFSPV LFLGIALVLW SVIPVKYSVV SVNLSLMLII GLSSLSVYSL
     LGSGWSSNSN YSFLGAVRAV AQTVSYEISL GLILLGVVLF AGGFNVEVIE SSQSWSWLMF
     SCFPLFAIWF VSTLAETNRA PFDLTEGESE IVSGYNVEYA GGPFAMFFIA EYANIIFINL
     LSVLLFLGGS SPMGEFFPVN VLVVSLKAGV LVLLFLWVRA SYPRFRYDQL MYLTWKKYLP
     LSLSFLVFFV VLLGVLDSLP PSSCFL