NU1M_PECMA
ID NU1M_PECMA Reviewed; 354 AA.
AC Q96186;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1;
OS Pecten maximus (King scallop) (Pilgrim's clam).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae; Pecten.
OX NCBI_TaxID=6579;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Muscle;
RX PubMed=7666448; DOI=10.1007/bf00170672;
RA Rigaa A., Monnerot M., Sellos D.;
RT "Molecular cloning and complete nucleotide sequence of the repeated unit
RT and flanking gene of the scallop Pecten maximus mitochondrial DNA: putative
RT replication origin features.";
RL J. Mol. Evol. 41:189-195(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; X92688; CAA63369.1; -; Genomic_DNA.
DR AlphaFoldDB; Q96186; -.
DR SMR; Q96186; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..354
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117448"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 354 AA; 39605 MW; 05640F882B3DEE9C CRC64;
MGGSFLQSWL NKALSWPGWY KWYWWLTSTK SLSIGRLVCV EALFWSLSFY VVVLLSVAYL
TLFERKVLAA SQVRKGPEMV GWLGIMQPFA DGIKLFSKEY FTPSNSNPAL FFLGPCFMLL
HSFILWGCSP GIWGCGVYFF WGGLYVLSVL SVGVYGVVLC GWSSNSRYAM FGAVRALAQV
ISYEVMLVFL YLCPFFVVGS LDLESVSLSQ VSGCNGGVLF LVLPWWVFCV LAESNRAPFD
FVEGESELVS GFNVEYGSGG FAMIFIAEYS NILFLSTLTS VLFLGGGNLL GNGEYFGLIS
SSVIGSFFSF MVVFLIVLCR SSFPRYRYDM LMKLIWCQIL PILMSCFALF LMII
