NU1M_PELSU
ID NU1M_PELSU Reviewed; 322 AA.
AC O79670;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Pelomedusa subrufa (African side-necked turtle).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Pleurodira; Pelomedusidae;
OC Pelomedusa.
OX NCBI_TaxID=44522;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9826682; DOI=10.1073/pnas.95.24.14226;
RA Zardoya R., Meyer A.;
RT "Complete mitochondrial genome suggests diapsid affinities of turtles.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:14226-14231(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AF039066; AAD05050.1; -; Genomic_DNA.
DR PIR; T11101; T11101.
DR RefSeq; NP_008432.1; NC_001947.1.
DR AlphaFoldDB; O79670; -.
DR SMR; O79670; -.
DR GeneID; 808281; -.
DR CTD; 4535; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..322
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117449"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 36094 MW; 54548325B2462EC0 CRC64;
MSIMMNLLQP LAFILPILIA VSFFTLVERK VISCMQPRKG PNITGPFGLL QPLADGLKLL
FKEPVYPTNS STTLFILTPT MALSLALSTW LPMPLPFSLV DLNLGLLFLL SMSSLMVFSI
LWSGWASNSK YALMGALRAV AQTISYEITL SLILLSMVLF SGGFNMRTFM TTQEQIYLIF
SSWPLAMMWY ISTLAETNRA PFDLAEGESE LVSGFNVEYA GGPFAAFFMA EYTSILMMNT
LSTILFLNPG FMYTSPTIFS ISLMTTAVAL SMGFLWIRAT YPRFRYDQLM HLLWKNFLPI
TLAWCLWHIS LLVTTSGIPP ML
