NU1M_PIG
ID NU1M_PIG Reviewed; 318 AA.
AC O79874; Q9TDR5;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Sus scrofa (Pig).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9732457; DOI=10.1007/pl00006388;
RA Ursing B.M., Arnason U.;
RT "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL J. Mol. Evol. 47:302-306(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Landrace;
RX PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA Mao S.J.T., Huang M.C.;
RT "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT dating evolutionary divergence within artiodactyla.";
RL Gene 236:107-114(1999).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03886}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03886};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AJ002189; CAA05229.1; -; Genomic_DNA.
DR EMBL; AF034253; AAD34185.1; -; Genomic_DNA.
DR PIR; T10972; T10972.
DR RefSeq; NP_008634.1; NC_000845.1.
DR PDB; 5GPN; EM; 5.40 A; e=1-318.
DR PDB; 5GUP; EM; 4.00 A; r=1-318.
DR PDB; 7V2C; EM; 2.90 A; s=1-318.
DR PDB; 7V2D; EM; 3.30 A; s=1-318.
DR PDB; 7V2E; EM; 2.80 A; s=1-318.
DR PDB; 7V2F; EM; 3.10 A; s=1-318.
DR PDB; 7V2H; EM; 2.50 A; s=1-318.
DR PDB; 7V2K; EM; 2.70 A; s=1-318.
DR PDB; 7V2R; EM; 2.60 A; s=1-318.
DR PDB; 7V30; EM; 2.70 A; s=1-318.
DR PDB; 7V31; EM; 2.90 A; s=1-318.
DR PDB; 7V32; EM; 3.20 A; s=1-318.
DR PDB; 7V33; EM; 2.60 A; s=1-318.
DR PDB; 7V3M; EM; 2.90 A; s=1-318.
DR PDB; 7VBL; EM; 2.60 A; s=1-318.
DR PDB; 7VBP; EM; 2.80 A; s=1-318.
DR PDB; 7VC0; EM; 2.60 A; s=1-318.
DR PDB; 7VWL; EM; 2.70 A; s=1-318.
DR PDBsum; 5GPN; -.
DR PDBsum; 5GUP; -.
DR PDBsum; 7V2C; -.
DR PDBsum; 7V2D; -.
DR PDBsum; 7V2E; -.
DR PDBsum; 7V2F; -.
DR PDBsum; 7V2H; -.
DR PDBsum; 7V2K; -.
DR PDBsum; 7V2R; -.
DR PDBsum; 7V30; -.
DR PDBsum; 7V31; -.
DR PDBsum; 7V32; -.
DR PDBsum; 7V33; -.
DR PDBsum; 7V3M; -.
DR PDBsum; 7VBL; -.
DR PDBsum; 7VBP; -.
DR PDBsum; 7VC0; -.
DR PDBsum; 7VWL; -.
DR AlphaFoldDB; O79874; -.
DR SMR; O79874; -.
DR STRING; 9823.ENSSSCP00000019135; -.
DR PaxDb; O79874; -.
DR PeptideAtlas; O79874; -.
DR GeneID; 808501; -.
DR KEGG; ssc:808501; -.
DR CTD; 4535; -.
DR eggNOG; KOG4770; Eukaryota.
DR HOGENOM; CLU_015134_0_1_1; -.
DR InParanoid; O79874; -.
DR OrthoDB; 1214989at2759; -.
DR TreeFam; TF352957; -.
DR ChiTaRS; ND1; pig.
DR Proteomes; UP000008227; Mitochondrion.
DR Proteomes; UP000314985; Mitochondrion.
DR Genevisible; O79874; SS.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..318
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117457"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 56
FT /note="F -> V (in Ref. 2; AAD34185)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="A -> G (in Ref. 2; AAD34185)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="A -> G (in Ref. 2; AAD34185)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35648 MW; A2534BC3CEE5C848 CRC64;
MFMINILSLI IPILLAVAFL TLVERKVLGY MQLRKGPNVV GPYGLLQPIA DALKLFTKEP
LRPATSSISM FIIAPILALS LALTMWVPLP MPYPLINMNL GVLFMLAMSS LAVYSILWSG
WASNSKYALI GALRAVAQTI SYEVTLAIIL LSVLLMNGSY TLSTLITTQE HIWMIFTSWP
LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF AMFFMAEYAN IIMMNAFTAI
LFLGASHDPH TPELYTINFV LKTLALTITF LWIRASYPRF RYDQLMHLLW KSFLPLTLAL
CMWHISLPIM TASIPPQS
