ID   NU1M_PODAN              Reviewed;         367 AA.
AC   P19041;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1;
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A, and s;
RX   PubMed=3197134; DOI=10.1007/bf00376746;
RA   Cummings D.J., Domenico J.M., Michel F.;
RT   "DNA sequence and organization of the mitochondrial ND1 gene from Podospora
RT   anserina: analysis of alternate splice sites.";
RL   Curr. Genet. 14:253-264(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=s;
RX   PubMed=2357736; DOI=10.1007/bf00334517;
RA   Cummings D.J., McNally K.L., Domenico J.M., Matsuura E.T.;
RT   "The complete DNA sequence of the mitochondrial genome of Podospora
RT   anserina.";
RL   Curr. Genet. 17:375-402(1990).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X55026; CAA38809.1; -; Genomic_DNA.
DR   EMBL; X13164; CAA31563.1; ALT_SEQ; Genomic_DNA.
DR   PIR; S06058; S06058.
DR   RefSeq; NP_074956.1; NC_001329.3.
DR   AlphaFoldDB; P19041; -.
DR   SMR; P19041; -.
DR   STRING; 515849.P19041; -.
DR   GeneID; 802490; -.
DR   KEGG; pan:PoanfMp49; -.
DR   Proteomes; UP000001197; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..367
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117459"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   367 AA;  41080 MW;  3AFC9D186EB25C2C CRC64;
     MYYSIIISLI EVVLVLVPAL LGIAYVTIAE RKTMASMQRR LGPNFVGYYG LLQAFADALK
     LLLKEYVAPT QANIILFFLG PVITLIFSLL GYAVIPYGPS LAINDFSLGI YYILAVSSLA
     TYGILLAGWS ANSKYAFLGS LRSTAQLISY ELVLSSAILL VIMLTGSLNL SVNIESQRAI
     WNIFPLLPVF IIFFIGSVAE TNRAPFDLAE AESELVSGFM TEHAAVVFVF FFLAEYGSIV
     LMCILTSILF LGGYLSINSL DVFNFFYSIL FNIGFIDLNF FNIFYYFYKE IFVNNSIIEG
     LIYGLTIGLK SSILIFLFIW VRASFPRIRF DQLMAFCWTV LLPLLFALIV LLPCILYSYN
     ILPVNVL