ID   NU1M_PONAB              Reviewed;         318 AA.
AC   P92690;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8875856; DOI=10.1007/bf02337514;
RA   Xu X., Arnason U.;
RT   "The mitochondrial DNA molecule of Sumatran orangutan and a molecular
RT   proposal for two (Bornean and Sumatran) species of orangutan.";
RL   J. Mol. Evol. 43:431-437(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03886}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03886};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03887}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X97707; CAA66283.1; -; Genomic_DNA.
DR   RefSeq; NP_007835.1; NC_002083.1.
DR   AlphaFoldDB; P92690; -.
DR   SMR; P92690; -.
DR   STRING; 9601.ENSPPYP00000023439; -.
DR   Ensembl; ENSPPYT00000024424; ENSPPYP00000023439; ENSPPYG00000020945.
DR   GeneID; 808473; -.
DR   KEGG; pon:808473; -.
DR   CTD; 4535; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   GeneTree; ENSGT00390000006621; -.
DR   HOGENOM; CLU_015134_0_1_1; -.
DR   InParanoid; P92690; -.
DR   OMA; WSGWASN; -.
DR   OrthoDB; 1214989at2759; -.
DR   TreeFam; TF352957; -.
DR   Proteomes; UP000001595; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..318
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117461"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  35512 MW;  94E56A76978EC77A CRC64;
     MPMINLLLLI MSILIAMAFL MLTERKILGH TQLRKGPNIV GPYGLLQPFA DALKLFTKEP
     LKPSTSTITL YIISPALALT IALLLWTPLP MPIPLINLNL GLLFILAASS LTVYSILWSG
     WASNSNYALI GALRAVAQTI SYEITLALIL LSVLLMSGSF NLSALITTQE HSWLLLPSWP
     LALMWFISTL AETNRAPFDL TEGESELVSG FNTEYAAGPF ALFFMAEYTN IILMNALTTM
     IFLGTTFNIH SPELYTTLFT IKTLLLTSLF LWIRSTYPRF RYDQLMHLLW KNFLPLTLAL
     LMWHISVPIA TSGIPPQT