NU1M_RABIT
ID NU1M_RABIT Reviewed; 318 AA.
AC O79427;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03886};
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Oryctolagus cuniculus (Rabbit).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000312|Proteomes:UP000001811};
RX PubMed=9653643; DOI=10.1006/geno.1998.5282;
RA Gissi C., Gullberg A., Arnason U.;
RT "The complete mitochondrial DNA sequence of the rabbit, Oryctolagus
RT cuniculus.";
RL Genomics 50:161-169(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03886}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03886};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03887}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03887}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AJ001588; CAA04847.1; -; Genomic_DNA.
DR PIR; T11480; T11480.
DR RefSeq; NP_007549.1; NC_001913.1.
DR AlphaFoldDB; O79427; -.
DR SMR; O79427; -.
DR STRING; 9986.ENSOCUP00000026179; -.
DR Ensembl; ENSOCUT00000033111; ENSOCUP00000026179; ENSOCUG00000029086.
DR GeneID; 808226; -.
DR KEGG; ocu:808226; -.
DR CTD; 4535; -.
DR eggNOG; KOG4770; Eukaryota.
DR GeneTree; ENSGT00390000006621; -.
DR HOGENOM; CLU_015134_0_1_1; -.
DR InParanoid; O79427; -.
DR OMA; WSGWASN; -.
DR OrthoDB; 1214989at2759; -.
DR TreeFam; TF352957; -.
DR Proteomes; UP000001811; Mitochondrion.
DR Bgee; ENSOCUG00000029086; Expressed in frontal cortex and 17 other tissues.
DR ExpressionAtlas; O79427; baseline.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..318
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117466"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 318 AA; 35775 MW; D41C31968A925FC2 CRC64;
MFLINTLLLI LPVLLAMAFL TLVERKILGY MQLRKGPNIV GPYGLLQPIA DAIKLFTKEP
LRPLTSSPLL FIIAPTLALT LALSMWLPIP MPYPLVNLNM GILFILATSS LAVYSILWSG
WASNSKYALF GALRAVAQTI SYEVTLAIIL LCILLMNGSF TLSSLITTQE YMWILLPAWP
LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAGGPF ALFFLAEYTN IILMNALTAI
LFLGSFHSHT NPEMFTVNFA TKTLLLTMTF LWIRASYPRF RYDQLMHLLW KSFLPLTLAL
CMWHISMPIM LSSIPPQM