NU1M_SALSA
ID NU1M_SALSA Reviewed; 324 AA.
AC Q37676;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Salmo salar (Atlantic salmon).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=10548724; DOI=10.1016/s0378-1119(99)00425-4;
RA Hurst C.D., Bartlett S.E., Davidson W.S., Bruce I.J.;
RT "The complete mitochondrial DNA sequence of the Atlantic salmon, Salmo
RT salar.";
RL Gene 239:237-242(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Arnason U., Johnsson E., Rasmussen A.S.;
RT "The complete mitochondrial genome sequence of a teleost, Salmo salar, and
RT comparisons with other salmoniformes.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; U12143; AAD04733.1; -; Genomic_DNA.
DR EMBL; AF133701; AAF61378.1; -; Genomic_DNA.
DR PIR; T09947; T09947.
DR RefSeq; NP_008445.1; NC_001960.1.
DR AlphaFoldDB; Q37676; -.
DR SMR; Q37676; -.
DR STRING; 8030.ENSSSAP00000000002; -.
DR GeneID; 808311; -.
DR KEGG; sasa:808311; -.
DR CTD; 4535; -.
DR OMA; WSGWASN; -.
DR OrthoDB; 1214989at2759; -.
DR Proteomes; UP000087266; Mitochondrion MT.
DR Bgee; ENSSSAG00000000007; Expressed in mesonephros and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..324
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117473"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 324 AA; 35452 MW; A0ED84E993C9D561 CRC64;
MTTTLITHII NPLAYIVPVL LAVAFLTLLE RKVLGYMQLR KGPNIVGPYG LLQPIADGLK
LFIKEPVRPS TSSPFLFLAT PMLALTLALT LWAPMPIPYP ITDLNLGVLF VLALSSLAVY
SILGSGWASN SKYALIGALR AVAQTISYEV SLGLILLSVI IFTGGFTLQT FNVAQESIWL
LVPAWPLAAM WYISTLAETN RAPFDLTEGE SELVSGFNVE YAGGPFALFF LAEYANILLM
NTLSAILFLG ASHIPAFPEL TAVNLMTKAA LLSVVFLWVR ASYPRFRYDQ LMHLVWKSFL
PLTLALVLWH LALPTAMAGL PPQL