NU1M_STRCA
ID NU1M_STRCA Reviewed; 324 AA.
AC O21397; O79099;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-MAR-2002, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Struthio camelus (Common ostrich).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC Struthio.
OX NCBI_TaxID=8801;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9214748; DOI=10.1093/oxfordjournals.molbev.a025815;
RA Harlid A., Janke A., Arnason U.;
RT "The mtDNA sequence of the ostrich and the divergence between paleognathous
RT and neognathous birds.";
RL Mol. Biol. Evol. 14:754-761(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.;
RT "Primers for a PCR-based approach to complete mitochondrial genome
RT sequencing.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11370967; DOI=10.1098/rspb.2001.1587;
RA Haddrath O., Baker A.J.;
RT "Complete mitochondrial DNA genome sequences of extinct birds: ratite
RT phylogenetics and the vicariance biogeography hypothesis.";
RL Proc. R. Soc. B 268:939-945(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; Y12025; CAA72744.1; -; Genomic_DNA.
DR EMBL; AF069429; AAD09383.1; -; Genomic_DNA.
DR EMBL; AF338715; AAK53351.1; -; Genomic_DNA.
DR PIR; A90612; A90612.
DR PIR; T11519; T11519.
DR RefSeq; NP_115441.1; NC_002785.1.
DR AlphaFoldDB; O21397; -.
DR SMR; O21397; -.
DR GeneID; 803281; -.
DR CTD; 4535; -.
DR OrthoDB; 1214989at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..324
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117481"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 141
FT /note="A -> G (in Ref. 1; CAA72744)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 35986 MW; C18A4479E60F13B8 CRC64;
MQFTIFTHLT MALSYAVPIL IAVAFLTLVE RKVLSYMQAR KGPNIVGPFG LLQPVADGVK
LFIKEPVRPT TSSPILFIAT PILALLLAIT IWIPLPLPFS LTDLNLGLLF LLSMSSLAVY
SILWSGWASN SKYALIGALR AVAQTISYEV TLAIILLSVI MLSGNYTLNT LATTQEPLYL
IFSTWPLAMM WYISTLAETN RAPFDLTEGE SELVSGFNVE YAAGPFALFF LAEYANIMLM
NTLTAILFLN PSSLNLPSEL FPLILATKTL LLSSGFLWVR ASYPRFRYDQ LMHLLWKNFL
PLTLALCLWH TSLPISYAGI PPHL