ID   NU1M_WHEAT              Reviewed;         325 AA.
AC   Q01148;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 1;
GN   Name=ND1; Synonyms=NAD1;
OS   Triticum aestivum (Wheat).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Thatcher;
RX   PubMed=1902143; DOI=10.1016/0092-8674(91)90464-a;
RA   Chapdelaine Y., Bonen L.;
RT   "The wheat mitochondrial gene for subunit I of the NADH dehydrogenase
RT   complex: a trans-splicing model for this gene-in-pieces.";
RL   Cell 65:465-472(1991).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- RNA EDITING: Modified_positions=1, 72, 103, 146, 164, 167, 179, 191,
CC       193, 194, 203, 225, 245, 248; Note=The initiator methionine is created
CC       by RNA editing.;
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR   EMBL; X57968; CAA41034.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X57967; CAA41034.1; JOINED; Genomic_DNA.
DR   EMBL; X57966; CAA41034.1; JOINED; Genomic_DNA.
DR   EMBL; X57965; CAA41034.1; JOINED; Genomic_DNA.
DR   PIR; A38489; DNWTU1.
DR   RefSeq; YP_398392.1; NC_007579.1.
DR   AlphaFoldDB; Q01148; -.
DR   SMR; Q01148; -.
DR   STRING; 4565.Traes_1AL_D647E23C6.1; -.
DR   PRIDE; Q01148; -.
DR   eggNOG; KOG4770; Eukaryota.
DR   ExpressionAtlas; Q01148; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; RNA editing; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..325
FT                   /note="NADH-ubiquinone oxidoreductase chain 1"
FT                   /id="PRO_0000117499"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   325 AA;  35932 MW;  BBD2BC996498CF53 CRC64;
     MYIAVPAEIL CLILPLLLGV AFLVLAERKV MAFVQRRKGP DVVGSFGLLQ PLADGLKLIL
     KEPISPSSAN FFLFRMAPVA TFMLSLVAWA VVPFDYGMVL SDLNIGLLYL FAISSLGVYG
     IIIAGWSSNS KYAFLGALRS AAQMVSYEVS IGLILITVLI CVGSCNLSEI VMAQKQIWFG
     IPLFPVLVMF FISCLAETNR APFDLPEAEA ELVAGYNVEY SSMGFALFFL GEYANMILMS
     GLCTLLFLGG WLPILDLPIS KKIPCSIWFS IKVLLFLFLY IWVRAAFPRY RYDQLMGLGR
     KVFLPLSLAR VVPVSGVSVT FRWLP