NU1M_YARLI
ID NU1M_YARLI Reviewed; 341 AA.
AC Q9B6E8;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=ND1;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OG Mitochondrion.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX DOI=10.1002/cfg.72;
RA Kerscher S., Durstewitz G., Casaregola S., Gaillardin C., Brandt U.;
RT "The complete mitochondrial genome of Yarrowia lipolytica.";
RL Comp. Funct. Genomics 2:80-90(2001).
RN [2]
RP SUBUNIT.
RX PubMed=15282186; DOI=10.1016/j.bbabio.2004.04.019;
RA Abdrakhmanova A., Zickermann V., Bostina M., Radermacher M., Schagger H.,
RA Kerscher S., Brandt U.;
RT "Subunit composition of mitochondrial complex I from the yeast Yarrowia
RT lipolytica.";
RL Biochim. Biophys. Acta 1658:148-156(2004).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBUNIT: Complex I is composed of 37 different subunits.
CC {ECO:0000269|PubMed:15282186}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AJ307410; CAC28089.2; -; Genomic_DNA.
DR RefSeq; NP_075424.2; NC_002659.1.
DR PDB; 6GCS; EM; 4.32 A; 1=1-341.
DR PDB; 6H8K; X-ray; 3.79 A; 1=1-335.
DR PDB; 6RFQ; EM; 3.30 A; 1=1-341.
DR PDB; 6RFR; EM; 3.20 A; 1=1-341.
DR PDB; 6RFS; EM; 4.04 A; 1=1-341.
DR PDB; 6Y79; EM; 3.20 A; 1=1-341.
DR PDB; 6YJ4; EM; 2.70 A; H=1-341.
DR PDBsum; 6GCS; -.
DR PDBsum; 6H8K; -.
DR PDBsum; 6RFQ; -.
DR PDBsum; 6RFR; -.
DR PDBsum; 6RFS; -.
DR PDBsum; 6Y79; -.
DR PDBsum; 6YJ4; -.
DR AlphaFoldDB; Q9B6E8; -.
DR SMR; Q9B6E8; -.
DR DIP; DIP-61436N; -.
DR IntAct; Q9B6E8; 2.
DR STRING; 284591.Q9B6E8; -.
DR GeneID; 802607; -.
DR KEGG; yli:YalifMp02; -.
DR InParanoid; Q9B6E8; -.
DR Proteomes; UP000001300; Mitochondrion.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..341
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117501"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..33
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 41..48
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 49..57
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:6RFQ"
FT HELIX 70..86
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 87..90
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 98..100
FT /evidence="ECO:0007829|PDB:6RFR"
FT HELIX 105..112
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 113..116
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 117..124
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 132..158
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 159..161
FT /evidence="ECO:0007829|PDB:6RFR"
FT HELIX 166..171
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 172..174
FT /evidence="ECO:0007829|PDB:6YJ4"
FT TURN 178..182
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 183..196
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 204..211
FT /evidence="ECO:0007829|PDB:6YJ4"
FT STRAND 212..216
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 222..246
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 256..262
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 268..299
FT /evidence="ECO:0007829|PDB:6YJ4"
FT HELIX 305..333
FT /evidence="ECO:0007829|PDB:6YJ4"
SQ SEQUENCE 341 AA; 38348 MW; A35BA04B1A89B6B9 CRC64;
MIINIVEILI FLVCVLFSVA YLTVAERKTL AYMQRRLGPN FVGYYGLLQA FADAVKLLLK
EIVLPKESNY IILVISPLIT LITALIGWVV IPLGPGITLG ELNLGILFSL AIGSLGVFGS
LLSGWSSNSK YSLLGSIRST AQLISYELIL TSIFIIIIMF VSSLNITTII ETQRVVWYCI
PLLPLLLIFF IASVAETARP PFDLTESESE LVAGYFTEYS GSPFVFFFLA EYSNIILISA
FNGYLLLGGY LSFNYSYLFN ILFNDYSYVS FLFEGLINSS AYAIKLVFLM FSFIWVRAAF
PRFTYDNLIN FCWIILLPLL FGIFLIIPST LYIFDSFPTL I
