NU205_DROME
ID NU205_DROME Reviewed; 2090 AA.
AC Q8IQV9; B6IDH1; Q3YMV0; Q8MSV6; Q9VWB8;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Nuclear pore complex protein Nup205 {ECO:0000305};
DE AltName: Full=205 kDa nucleoporin {ECO:0000312|FlyBase:FBgn0031078};
DE AltName: Full=Nucleoporin Nup205 {ECO:0000305};
GN Name=Nup205 {ECO:0000312|FlyBase:FBgn0031078};
GN ORFNames=CG11943 {ECO:0000312|FlyBase:FBgn0031078};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ACI88735.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley {ECO:0000312|EMBL:ACI88735.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:ACI88735.1};
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAY56649.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-787 (ISOFORM B).
RC TISSUE=Ovary {ECO:0000312|EMBL:AAY56649.1};
RX PubMed=15917496; DOI=10.1093/molbev/msi175;
RA Jagadeeshan S., Singh R.S.;
RT "Rapidly evolving genes of Drosophila: differing levels of selective
RT pressure in testis, ovary, and head tissues between sibling species.";
RL Mol. Biol. Evol. 22:1793-1801(2005).
RN [5] {ECO:0000312|EMBL:AAM49917.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-2090 (ISOFORM A/B).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6] {ECO:0000305}
RP FUNCTION.
RX PubMed=20547758; DOI=10.1128/mcb.00124-10;
RA Chen X., Xu L.;
RT "Specific nucleoporin requirement for Smad nuclear translocation.";
RL Mol. Cell. Biol. 30:4022-4034(2010).
CC -!- FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and
CC maintenance, but with limited role in NPC permeability. Required for
CC specific nuclear import pathways such as Mad import.
CC {ECO:0000269|PubMed:20547758}.
CC -!- SUBUNIT: Part of the nuclear pore complex (NPC).
CC {ECO:0000250|UniProtKB:Q92621}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q92621}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B {ECO:0000312|FlyBase:FBgn0031078};
CC IsoId=Q8IQV9-1; Sequence=Displayed;
CC Name=A {ECO:0000312|FlyBase:FBgn0031078};
CC IsoId=Q8IQV9-2; Sequence=VSP_059518;
CC -!- SIMILARITY: Belongs to the NUP186/NUP192/NUP205 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM49917.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAM49917.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=ACI88735.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014298; AAN09521.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF49028.2; -; Genomic_DNA.
DR EMBL; BT050409; ACI88735.1; ALT_FRAME; mRNA.
DR EMBL; DQ062776; AAY56649.1; -; mRNA.
DR EMBL; AY118548; AAM49917.1; ALT_SEQ; mRNA.
DR RefSeq; NP_608362.2; NM_134518.4. [Q8IQV9-2]
DR RefSeq; NP_728308.1; NM_167687.3. [Q8IQV9-1]
DR AlphaFoldDB; Q8IQV9; -.
DR SMR; Q8IQV9; -.
DR IntAct; Q8IQV9; 2.
DR MINT; Q8IQV9; -.
DR STRING; 7227.FBpp0074567; -.
DR PaxDb; Q8IQV9; -.
DR PRIDE; Q8IQV9; -.
DR EnsemblMetazoa; FBtr0074798; FBpp0074567; FBgn0031078. [Q8IQV9-1]
DR EnsemblMetazoa; FBtr0074799; FBpp0074568; FBgn0031078. [Q8IQV9-2]
DR GeneID; 33002; -.
DR KEGG; dme:Dmel_CG11943; -.
DR UCSC; CG11943-RB; d. melanogaster. [Q8IQV9-1]
DR CTD; 23165; -.
DR FlyBase; FBgn0031078; Nup205.
DR VEuPathDB; VectorBase:FBgn0031078; -.
DR eggNOG; KOG1835; Eukaryota.
DR GeneTree; ENSGT00390000004003; -.
DR InParanoid; Q8IQV9; -.
DR OMA; WSQMFAE; -.
DR PhylomeDB; Q8IQV9; -.
DR Reactome; R-DME-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DME-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DME-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DME-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
DR SignaLink; Q8IQV9; -.
DR BioGRID-ORCS; 33002; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33002; -.
DR PRO; PR:Q8IQV9; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0031078; Expressed in eye disc (Drosophila) and 21 other tissues.
DR ExpressionAtlas; Q8IQV9; baseline and differential.
DR Genevisible; Q8IQV9; DM.
DR GO; GO:0044611; C:nuclear pore inner ring; ISS:FlyBase.
DR GO; GO:0017056; F:structural constituent of nuclear pore; ISS:FlyBase.
DR GO; GO:0042332; P:gravitaxis; IMP:FlyBase.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006999; P:nuclear pore organization; ISS:FlyBase.
DR GO; GO:0006606; P:protein import into nucleus; IMP:FlyBase.
DR InterPro; IPR021827; Nup186/Nup192/Nup205.
DR PANTHER; PTHR31344; PTHR31344; 1.
DR Pfam; PF11894; Nup192; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..2090
FT /note="Nuclear pore complex protein Nup205"
FT /id="PRO_0000443734"
FT VAR_SEQ 1..25
FT /note="MDGECLANEQMCVGRQITNATHAST -> MD (in isoform A)"
FT /id="VSP_059518"
FT CONFLICT 123
FT /note="G -> C (in Ref. 3; ACI88735)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="E -> G (in Ref. 3; ACI88735)"
FT /evidence="ECO:0000305"
FT CONFLICT 1503
FT /note="I -> T (in Ref. 3; ACI88735)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2090 AA; 235147 MW; 32D2E6A6500F33FD CRC64;
MDGECLANEQ MCVGRQITNA THASTAVIED MWTPYKHLYN TFQTAVSNRS GFTSDLEQCL
KKYKHNFSNL LRNPPRSEKS RNLLRNALNE GVPMQGHSRK TKMSQDLADE AVILSDMFDL
DEGFAVELLC TAQRQQKHHP GLSRGLVAVL LYYDGRKAIS CTLRDMFQVV SGVSWNTELP
KEITGLVTNY AESLVDGSGI LGRLLQLLEE MDVDKECAML TTNRAFGSKK HQNQVLGLYE
DIQQALAMAL FNWSAQRGLP RHIAIRLMHQ LANRKNHDAG GNMDDVTLIM LMALLYAYDT
SMLLVTEEPN EHTTRLPIFS DREFAECFLE ELYAQSSWQA PRLNAIIAYS FGLTLASLRH
APLQLQATAI SIINRDEMLI DEALGAQVFV FFHSLLLEKD LVYSTQFFYR RVHLLITDFI
DFMNSKVSEL RGRADESSHT IISFLNEGLE PPPNLDSNFE LLMLCVAKMH GDPRVTIRLC
NEYWGPGDPN GSTAFKNTSR SVSLFKFISL ASDLLPQTLF KAYLKMISGL TRTDFSARCA
FNMLRVPQMA TGGKYAVSWD HFFTTLGNYY TSMRNDFNTN IGMSGETIYR TRSTPKAITQ
REAEHLVAVM GIIQAVAEHD EVSRIMICDH PNWQTPQVLL GLVACATPLF LKAEILHTLA
ALAKSKETAR VIWFHLEASQ IIPTVPVSRS YAQCSLLEEM EQIESRSEQY NLTRGILQLL
YTLMTTNLPK SLGAGQRTPA YEGYLKSMIN SVLLKFYNRA YKVPSEKWQV GAQCLKLLYY
LLATYRPSAM DFLETVDEPP YPGFHVMMQL QLKSEMLQLL LCIVEEVRER LDNYNRFQGK
KLLEECSLYA LLILEAALAK QNAFFEAHSA ANCPILLSGL NRMLLDLNPR SRKPDHVLNI
IKYVTYNSWL PRHALAAIKI LASVTQLPNV STQILSMYGQ GSNEKLEIRQ GFVECLEMEV
CVGKHDDDLL DQLALNNHVP YLGFGDDLDN EREMSGEREY STIESQLELQ AGDGALESKP
ASIELQLKEA IIKLFEMNLS QQLPNFVYFL LGVDVLREFM ANGRQHLAIE MQSSCVNSVV
LLLEKYMDKQ RHSDKYCEHT ARIVERIYHL FHGLCANRRT AETILRYFRL TCSDFLLRHL
RSLPFRQHRE DHVLHAMGHL LNCVSIDVKL AAKHGQMTRF NQMCDILLIG NGMERSSHGL
SMELGHSLIS QPSSSFLAMD VLPAGGSISA VAHGAGSASL GAPNTGVKSL KPSLLQETSQ
GLHVTRLLDI LVLEAGTLSQ PQLEFFDGHL ITQLLRDCEA SAEAGANSRA NLINVRKLYY
ILTDELYMVQ SIIASGQRKA ISTEIMLLLN HAVNINRVRT QRCATLAFMA AWGQLVQVLF
SNMPDAVLPA TQRRQHIIDI VEKVLIKVQP IQPIIEISVQ VSETVLLLLA NLRYCCYQAE
DQSPEDLAAE DSLSNGNGNA IGNDSQVNAL CLGQRAIGTG SDGGSGGGRD IGSGGNSSNL
RFILKNLVQW IMISEVKSQK LRINLYSSLL NCLRIAKRLR TDEHLEYQET LISRQESART
YNKEQRRDDR LRLKAMAAEV IGTFGEKLID TICHDAVTGH DVCRMLALAC LDMISELQAV
STLCDFVASR GYLKHILESL DQSSTALCGI LQPVPDHLRP LYVYESRMAF LTRMANSNVG
ARLLLTEQAL GVLSNMKVYD QQPDLKSSEL NRNEPQTFLP SIDDRFRSIL LPALSLCDAI
VNSLGPRNNS AAVQVLNFLF AHIDMVEAML RSATPYMDLG HLQQVAVISN LFARASTHEL
TALEDSVQLD LRNRLGRVQQ LMIVVFGRFC VSEPTIRRML QQDEEQQTNP TDDSKRLRVK
YFLDIAANVS LYCRNVVTSH SKDSMTSKYL LTTVINDVTL LTGKMSSKKL TTIMHTILNQ
LKGSIGYYLS QKSIADNLLQ QRASLPNISF GPNGKQSYIE LSQRYNEKRS ELRQAVFIAE
QNLYLLWIHL DFYLRNTIDY ANENRNAINE SNMDDDNDMS VLNASQEEIV QLKQLLISTF
NETFCTQLIN ASEDYSIKCK GFNGSLLRRI KALVQFAPIT ANDVNSSFDS
