NU2M_ALBCA
ID NU2M_ALBCA Reviewed; 307 AA.
AC P48902;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2;
OS Albinaria caerulea (Land snail).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC Helicina; Clausilioidea; Clausiliidae; Alopiinae; Albinaria.
OX NCBI_TaxID=42349;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7498775; DOI=10.1093/genetics/140.4.1353;
RA Hatzoglou E., Rodakis G.C., Lecanidou R.;
RT "Complete sequence and gene organization of the mitochondrial genome of the
RT land snail Albinaria coerulea.";
RL Genetics 140:1353-1366(1995).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; X83390; CAA58306.1; -; Genomic_DNA.
DR PIR; S59153; S59153.
DR RefSeq; NP_007339.1; NC_001761.1.
DR AlphaFoldDB; P48902; -.
DR SMR; P48902; -.
DR GeneID; 808000; -.
DR CTD; 4536; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF00361; Proton_antipo_M; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..307
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117540"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 307 AA; 34865 MW; CF27C405278CB92D CRC64;
MTLQSVLLGA MIILGPILSM TSSNWIIIWI GLEISLLGFV SYYMLMKKIM SGEGIMMYFL
IQSVSSTVML LNGLYIFVNH ASSYIYLFIF ITMLMLKIGM FPLHFWIIPV YSKLSYLNIG
IVGLLLKIVP MWILMHMGCI TSEMLNLITM LSVTSMLFGA LIGMNLSKMR MVLGASTITH
NGWLGMSCIS GSLFKYFITY GFSLVILLVF LYLGDKMSIS LSLLSLSGLP PFMLFIGKIN
VLLMMMETNL WFIVLVFAIL SAVISLVYYL KFSVMFFMNM KNNYLKHYKM AMFLLVNVTF
GMLLFLT