ID   NU2M_CANAL              Reviewed;         475 AA.
AC   Q9B8D2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=NAD2; OrderedLocusNames=CM_00310W {ECO:0000312|CGD:CAL0000182977};
GN   ORFNames=CaalfMp09;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11208783; DOI=10.1128/jb.183.3.865-872.2001;
RA   Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T.,
RA   Kohn L.M.;
RT   "Infrequent genetic exchange and recombination in the mitochondrial genome
RT   of Candida albicans.";
RL   J. Bacteriol. 183:865-872(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; AF285261; AAG59594.2; -; Genomic_DNA.
DR   RefSeq; NP_075037.2; NC_002653.1.
DR   AlphaFoldDB; Q9B8D2; -.
DR   SMR; Q9B8D2; -.
DR   STRING; 237561.Q9B8D2; -.
DR   GeneID; 802559; -.
DR   KEGG; cal:CaalfMp09; -.
DR   CGD; CAL0000182977; NAD2.
DR   VEuPathDB; FungiDB:CM_00310W; -.
DR   InParanoid; Q9B8D2; -.
DR   Proteomes; UP000000559; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:CGD.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:CGD.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:CGD.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..475
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000356876"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   475 AA;  53320 MW;  4D69C55652703418 CRC64;
     MVVHITTDND IGVRITLRRM LLLTLVTYIV YIAYNQRDIL HINRLAVLAL SFVAYLAWES
     IGIQYSNFTL LNDWFQYTPG NAPIVLLLII LVITLLVYLT TTQRYITPNK WIALLMLVNL
     IGLILFPMVN DLIPLYVIIE LQSYSLYLLT GVYNKSYNAT RAAILYFVTG GIASVLILLS
     SAEVYEATGL TNLSEISTYY SISGINTWTS FDILLIALVF KMGLAPLHAW SISVYSYAPL
     YITAYISIVA KVSIMSFIYL NIHLFSTQLL ILAFYLSVAV AAYTPLYQVN IKSILAYSGI
     LNFGYLLTAV LTNDNAYYIY IIQYSLTHVT IFLCILAITE YTNKPASYWS PIVNVNQLVV
     PNKALCIALI VCLFSLIGIP PLPGFYGKYY IIVGLMSNGL NLEALTIIVF SVIATYYYAY
     IIKQLASNLY NNNTNVIATP INSTLGFIIS ILMVILITFY MYLPTLLDGL TLLHS