ID   NU2M_CHOCR              Reviewed;         497 AA.
AC   P48903;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=ND2; Synonyms=NAD2;
OS   Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa).
OG   Mitochondrion.
OC   Eukaryota; Rhodophyta; Florideophyceae; Rhodymeniophycidae; Gigartinales;
OC   Gigartinaceae; Chondrus.
OX   NCBI_TaxID=2769;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Apices;
RX   PubMed=7616569; DOI=10.1006/jmbi.1995.0392;
RA   Leblanc C., Boyen C., Richard O., Bonnard G., Grienenberger J.-M.,
RA   Kloareg B.;
RT   "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus
RT   crispus (Gigartinales). Gene content and genome organization.";
RL   J. Mol. Biol. 250:484-495(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; Z47547; CAA87619.1; -; Genomic_DNA.
DR   PIR; S59103; S59103.
DR   RefSeq; NP_062494.1; NC_001677.2.
DR   AlphaFoldDB; P48903; -.
DR   SMR; P48903; -.
DR   GeneID; 809390; -.
DR   KEGG; ccp:ChcroMp15; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   HAMAP; MF_00445; NDH1_NuoN_1; 1.
DR   InterPro; IPR010096; NADH-Q_OxRdtase_suN/2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   TIGRFAMs; TIGR01770; NDH_I_N; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..497
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117571"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   497 AA;  56854 MW;  DB00BF38039F40CA CRC64;
     MNNFLYDIYP ILPEIFILSN VCILLVYGVL FSSSIKLGYP LLAQNLGLLS CQILGCSFII
     TYYQTFLNLS SWSDFFINDI FTFKTKCLIF LMCLGWILIT FSYINYERIN SFEYWILILL
     AIVAILFIIQ SYDLLTMYLS IEFQSLIFYI LASFKRTSEF STEAGLKYFV LGAFSSGLLL
     FGSSLIYGLT GLTNFLDLAK FFTGMPMLEL SSWIGLTTGF TLILVSLLFK LSAAPFHMWA
     PDVYEGSPTS ITLFFSIMPK LAILSLLLKL LILSFHDFIT FWRIIILICI IFSIMIGTLS
     AFSQIKWKRF IAYSSISHVG FFLLAILSGN LEGISSSIFY VIIYVITMLG IFSFILTLRF
     YNYSYHYQTR YLQDLISLSR FNPALAISLT LFLFSMAGIP PLGGFFAKLF VLLSVLQTKS
     FGISIFVVLM SCISCFYYIK LIKSMYFSSI NEWKVLYPIN KLNSLLLGFS LLFISFIFYD
     IELLSILSTL MSFSFLN