ID   NU2M_COTJA              Reviewed;         346 AA.
AC   P24971; Q8SEX2;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   26-SEP-2003, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1706782; DOI=10.1007/bf02515387;
RA   Desjardins P., Morais R.;
RT   "Nucleotide sequence and evolution of coding and noncoding regions of a
RT   quail mitochondrial genome.";
RL   J. Mol. Evol. 32:153-161(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=11736810; DOI=10.1046/j.1365-2052.2001.00795.x;
RA   Nishibori M., Hayashi T., Tsudzuki M., Yamamoto Y., Yasue H.;
RT   "Complete sequence of the Japanese quail (Coturnix japonica) mitochondrial
RT   genome and its genetic relationship with related species.";
RL   Anim. Genet. 32:380-385(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; X57246; CAA40523.1; -; Genomic_DNA.
DR   EMBL; AP003195; BAB62916.1; -; Genomic_DNA.
DR   PIR; S25423; S25423.
DR   RefSeq; NP_572015.1; NC_003408.1.
DR   AlphaFoldDB; P24971; -.
DR   SMR; P24971; -.
DR   Ensembl; ENSCJPT00005000011; ENSCJPP00005000003; ENSCJPG00005000011.
DR   GeneID; 804667; -.
DR   KEGG; cjo:804667; -.
DR   CTD; 4536; -.
DR   GeneTree; ENSGT00730000111348; -.
DR   OrthoDB; 1153818at2759; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..346
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117572"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  38087 MW;  F4CFF5AD44ACC392 CRC64;
     MNPHAKLISI MSLALGTSIT ISSNHWILAW TGLEINTLAI IPLISKSHHP RAIEAAIKYF
     LTQSTASALI LFSSMNNAWS TGQWDITQLN HPTSCLILTM AIAIKLGLVP FHFWFPEVLQ
     GSSLITALLL STLMKLPPMT LLLMTSQSLN PALLTLLAVS SALVGGWMGL NQTQTRKILA
     FSSISHLGWM IVIIIYNPKL TILTFIIYSL MTSTVFLSLS QIKVLKLSTM LISWTKTPML
     NSTIMVTLLS LAGLPPLTGF MPKWLIIQEL TKQEMTPVAT TIAMLSLLGL FFYLRLAYHS
     TITLPPNSSN HMKLWRINTT PNTPTAILTV LSISLLPLSP LITTLV