ID   NU2M_CYPCA              Reviewed;         348 AA.
AC   P24972;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS   Cyprinus carpio (Common carp).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8169959; DOI=10.1007/bf00166161;
RA   Chang Y.S., Huang F.L., Lo T.B.;
RT   "The complete nucleotide sequence and gene organization of carp (Cyprinus
RT   carpio) mitochondrial genome.";
RL   J. Mol. Evol. 38:138-155(1994).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; X61010; CAA43333.1; -; Genomic_DNA.
DR   PIR; S36003; S36003.
DR   RefSeq; NP_007083.1; NC_001606.1.
DR   AlphaFoldDB; P24972; -.
DR   SMR; P24972; -.
DR   Ensembl; ENSCCRT00000000011; ENSCCRP00000000003; ENSCCRG00000000011.
DR   GeneID; 807766; -.
DR   KEGG; ccar:807766; -.
DR   CTD; 4536; -.
DR   GeneTree; ENSGT00730000111348; -.
DR   OrthoDB; 1153818at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..348
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117576"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  37851 MW;  B0FF1C0351277899 CRC64;
     MNPYRRATLL CSVGLGTTLT FASSHWLLAW MGLEINTLAI TPLMAQHHHP RAVEATTKYF
     LTQATAAAMI LFASTTNAWM TGEWSINDLS NPIASTMFMA ALALKIGLAP MHFWMPEVLQ
     GLDLLTGLIL STWQKLAPLA LIIQTAQTID PLLLTLLGIS STLVGGWGGL NQTQLRKILA
     YSSIAHMGWM IIVIQYAPQL TLIALGTYII MTSAAFLTLK MSLTTKISTL ATTWSKSPIL
     TSTTALVLLS LGGLPPLTGF MPKWLILQEL TKQDLPIIAT AMALTALISL YFYLRLLYAM
     TLTISPNMIN STTPWRTQTT QTSLPLALFT TAALGLLPMA PAILMLTT