NU2M_DANRE
ID NU2M_DANRE Reviewed; 348 AA.
AC Q9MIY9;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03891};
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=mt-nd2; Synonyms=mtnd2, nd2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX PubMed=11691861; DOI=10.1101/gr.156801;
RA Broughton R.E., Milam J.E., Roe B.A.;
RT "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome
RT and evolutionary patterns in vertebrate mitochondrial DNA.";
RL Genome Res. 11:1958-1967(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03891}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03891};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03892}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; AC024175; AAF74298.1; -; Genomic_DNA.
DR RefSeq; NP_059332.1; NC_002333.2.
DR AlphaFoldDB; Q9MIY9; -.
DR SMR; Q9MIY9; -.
DR STRING; 7955.ENSDARP00000087870; -.
DR PaxDb; Q9MIY9; -.
DR Ensembl; ENSDART00000093600; ENSDARP00000087870; ENSDARG00000063899.
DR GeneID; 140532; -.
DR KEGG; dre:140532; -.
DR CTD; 4536; -.
DR ZFIN; ZDB-GENE-011205-8; mt-nd2.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111348; -.
DR HOGENOM; CLU_007100_1_3_1; -.
DR InParanoid; Q9MIY9; -.
DR OMA; HFWVPEV; -.
DR OrthoDB; 1153818at2759; -.
DR PhylomeDB; Q9MIY9; -.
DR TreeFam; TF343996; -.
DR Reactome; R-DRE-611105; Respiratory electron transport.
DR Reactome; R-DRE-6799198; Complex I biogenesis.
DR PRO; PR:Q9MIY9; -.
DR Proteomes; UP000000437; Mitochondrion MT.
DR Proteomes; UP000814640; Mitochondrion.
DR Bgee; ENSDARG00000063899; Expressed in early embryo and 36 other tissues.
DR ExpressionAtlas; Q9MIY9; baseline.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..348
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117562"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 348 AA; 37721 MW; 348AEF27591FAEFE CRC64;
MNPYVLMILM SSLGLGTTLT FSSSHWILAW MGLEINTLAI VPLMAQQHHP RAVEATTKYF
LIQAAAAAMI LFTSTTNAWI SGQWDVTGMP GPATSTAMMF ALALKIGLAP MHFWLPEVLQ
GLDLLTGLIL STWQKLAPMA LIIQTTQTTD PLILTSLGIA SSLIGGWSGL NQTQLRKILA
YSSIAHMGWM IIVIQYAPQL TLIALGTYIF MTSAAFLTLK VLSATKINTL TTTWPKSPIL
AAIATLVMLS LGGLPPLTGF MPKWLILQEL TKQDLPATAT IMALTALLSL FFYLRLCHAM
TLTTSPNTIN SAPHWRVQTT QNSLPLTISV TVTMGLLPLT PAILMLTT
