NU2M_DROYA
ID NU2M_DROYA Reviewed; 341 AA.
AC P03895;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=mt:ND2; Synonyms=ND2;
OS Drosophila yakuba (Fruit fly).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6314262; DOI=10.1093/nar/11.19.6859;
RA Clary D.O., Wolstenholme D.R.;
RT "Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in
RT Drosophila mitochondrial DNA.";
RL Nucleic Acids Res. 11:6859-6872(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2317.6 Ivory Coast;
RX PubMed=3001325; DOI=10.1007/bf02099755;
RA Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence,
RT gene organization, and genetic code.";
RL J. Mol. Evol. 22:252-271(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
RX PubMed=6294611; DOI=10.1093/nar/10.21.6619;
RA Clary D.O., Goddard J.M., Martin S.C., Fauron C.M.-R., Wolstenholme D.R.;
RT "Drosophila mitochondrial DNA: a novel gene order.";
RL Nucleic Acids Res. 10:6619-6637(1982).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
RX PubMed=3116271; DOI=10.1007/bf02101753;
RA Clary D.O., Wolstenholme D.R.;
RT "Drosophila mitochondrial DNA: conserved sequences in the A + T-rich region
RT and supporting evidence for a secondary structure model of the small
RT ribosomal RNA.";
RL J. Mol. Evol. 25:116-125(1987).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; X05915; CAA29342.1; -; Genomic_DNA.
DR EMBL; X03240; CAA26985.1; -; Genomic_DNA.
DR PIR; B93488; QXFF2Y.
DR RefSeq; NP_006902.1; NC_001322.1.
DR AlphaFoldDB; P03895; -.
DR SMR; P03895; -.
DR PRIDE; P03895; -.
DR GeneID; 807621; -.
DR KEGG; dya:ND2; -.
DR CTD; 4536; -.
DR FlyBase; FBgn0013184; Dyak\mt:ND2.
DR Proteomes; UP000002282; Mitochondrion.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..341
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117584"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 341 AA; 39496 MW; E6117DE50BE9D4AF CRC64;
MFYNSSKILF TTIMIIGTLI TVTSNSWLGA WMGLEINLLS FIPLLSDNNN LMSTEASLKY
FLTQALASTV LLFSSILLML ANNLNNEINE SFTSMIIMSA LLLKSGAAPF HFWFPNMMEG
LTWMNALMLM TWQKIAPLML ISYLNIKNLL LISVILSVII GAIGGLNQTS LRKLMAFSSI
NHLGWMLSSL MISESIWLIY FIFYSFLSFV LTFMFNIFKL FHLNQLFSWF VNSKILKFSL
FMNFLSLGGL PPFLGFLPKW LVIQQLTMCN QYFLLTLMMM STLITLFFYL RICYSAFMLN
YFENNWIMEM NMNSNNTNLY LIMTFFSIFG LFLISLFFFM L
