ID   NU2M_GADMO              Reviewed;         348 AA.
AC   P55780;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS   Gadus morhua (Atlantic cod).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Norwegian coastal 1;
RX   PubMed=8018725; DOI=10.1016/0167-4781(94)90015-9;
RA   Johansen S., Johansen T.;
RT   "Sequence analysis of 12 structural genes and a novel non-coding region
RT   from mitochondrial DNA of Atlantic cod, Gadus morhua.";
RL   Biochim. Biophys. Acta 1218:213-217(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Norwegian coastal 1;
RX   PubMed=8817926;
RA   Johansen S., Bakke I.;
RT   "The complete mitochondrial DNA sequence of Atlantic cod (Gadus morhua):
RT   relevance to taxonomic studies among codfishes.";
RL   Mol. Mar. Biol. Biotechnol. 5:203-214(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; X76363; CAA53964.1; -; Genomic_DNA.
DR   EMBL; X99772; CAA68107.1; -; Genomic_DNA.
DR   PIR; S45350; S45350.
DR   RefSeq; NP_008614.1; NC_002081.1.
DR   AlphaFoldDB; P55780; -.
DR   SMR; P55780; -.
DR   GeneID; 808445; -.
DR   CTD; 4536; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..348
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117588"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  37893 MW;  DA6EF3E3F0C1255D CRC64;
     MNPFILSILL LSLGLGTTLT FASSHWLLAW MGLEISTLAI IPLMSQHHHP RAVEATTKYF
     ITQAAAAALI LFASTTNAWI TGQWDINFDL HFFPASMLTM ALALKMGLAP VHFWLPEVLQ
     GLDLTTGLIL STWQKLAPFI LMCQIMPVNS SLITFLGVTS TLVGGWGGLN QTQLRKILAY
     SSIAHLGWMI LVMQFNQQLA LLALIIYIPM TFSTFMIFKT NSSTTVNTLA ASWAKTPALT
     AITPMILLSL GGLPPLSGFM PKWMILQELT KQDIPLTASI AALSALLSLY FYLRVSYAMT
     LTISPNNLNA TTPWRLQTTA STLPLAISAT ISAMLLPLAP ATLALLSL