NU2M_MARPO
ID NU2M_MARPO Reviewed; 489 AA.
AC P26846;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2; Synonyms=NAD2;
OS Marchantia polymorpha (Liverwort) (Marchantia aquatica).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta;
OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia.
OX NCBI_TaxID=3197;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1731062; DOI=10.1016/0022-2836(92)90708-r;
RA Oda K., Yamato K., Ohta E., Nakamura Y., Takemura M., Nozato N., Akashi K.,
RA Kanegae T., Ogura Y., Kohchi T., Ohyama K.;
RT "Gene organization deduced from the complete sequence of liverwort
RT Marchantia polymorpha mitochondrial DNA. A primitive form of plant
RT mitochondrial genome.";
RL J. Mol. Biol. 223:1-7(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8483448; DOI=10.1007/bf00279437;
RA Nozato N., Oda K., Yamato K., Ohta E., Takemura M., Akashi K., Fukuzawa H.,
RA Ohyama K.;
RT "Cotranscriptional expression of mitochondrial genes for subunits of NADH
RT dehydrogenase, nad5, nad4, nad2, in Marchantia polymorpha.";
RL Mol. Gen. Genet. 237:343-350(1993).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; M68929; AAC09399.1; -; Genomic_DNA.
DR PIR; S25943; S25943.
DR RefSeq; NP_054402.1; NC_001660.1.
DR AlphaFoldDB; P26846; -.
DR SMR; P26846; -.
DR GeneID; 2702662; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009536; C:plastid; IEA:UniProt.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR HAMAP; MF_00445; NDH1_NuoN_1; 1.
DR InterPro; IPR010096; NADH-Q_OxRdtase_suN/2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR TIGRFAMs; TIGR01770; NDH_I_N; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..489
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117605"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 489 AA; 54592 MW; E5773CC5A929365A CRC64;
MFEHDFLALF PEIFLINATI ILLIYGVVFS TSKKYDYPPL VRNVGWLGLL SVLITILLVA
VGSPLAVANL VYNNLIIDNF TYFCQIFLLL STASTMVMCL DYFKQESLNA FESIVLILLS
TCSMLFMISA YDLIAMYLAI ELQSLCFYVI AASKRDSEFS TEAGLKYFIL GAFSSGILLF
GCSMIYGFTG VTNFEELAKI FTGYEITLFG AQSSGIFMGI LFIAVGFLFK ITAVPFHMWA
PDVYEGSPTI VTAFFSIAPK ISILANMLRV FIYSFYDPTW QQLFFFCSIA SMILGALAAM
AQNKVKRLLA YSSIGHVGYL LIGFSCGTIE GIQSLLIGIF IYVLMTVNVF AIVLALRQNR
FKYIADLGAL AKTNPILAIT LSITMFSYAG IPPLAGFCSK FYLFFAALGC GAYLLALIGV
VTSVISCFYY IRFVKIMYFD TPKTWVLYKP MDREKSLLLA ITVFFITFFF LYPSPLFLVT
HQMALCLCL
