NU2M_MYTED
ID NU2M_MYTED Reviewed; 314 AA.
AC Q00229; Q68SR3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2;
OS Mytilus edulis (Blue mussel).
OG Mitochondrion.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC Mytilus.
OX NCBI_TaxID=6550;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 228.
RX PubMed=15014161; DOI=10.1093/molbev/msh090;
RA Boore J.L., Medina M., Rosenberg L.A.;
RT "Complete sequences of the highly rearranged molluscan mitochondrial
RT genomes of the scaphopod Graptacme eborea and the bivalve Mytilus edulis.";
RL Mol. Biol. Evol. 21:1492-1503(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-128 AND 226-314.
RX PubMed=1386586; DOI=10.1093/genetics/131.2.397;
RA Hoffmann R.J., Boore J.L., Brown W.M.;
RT "A novel mitochondrial genome organization for the blue mussel, Mytilus
RT edulis.";
RL Genetics 131:397-412(1992).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; AY484747; AAT98408.1; -; Genomic_DNA.
DR PIR; S28754; S28754.
DR RefSeq; YP_073341.1; NC_006161.1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF00361; Proton_antipo_M; 2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..314
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117609"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 314 AA; 33912 MW; A99793BC1A5822C8 CRC64;
MVVCGETMKL VSLGVMLIGT ILSVSSEELV GVWLGLELNL YGFLVIMNPD GHYSPEPCVK
YFVVQSTGSI LMLVGFVSLM EQHVVSGLVM STAXTVLKSG VFPLHSWVPS VIKNSSWLAS
GLMLTWQKVA PLVFLSMILP SKSLWVVIVS MAGIGAVGGL NQNSVRVMSA YSSFVHTSWM
LLGLTWSSVV FVGYFAVYSL SVGLFFYGCS LMNKMSMGSQ LSSAASGMGL LMLMGMPPFL
GFLAKVLVFL MSGSPVIVAC IMGSVISLKF YIDFFYSMVM KSLVDKNKVE VKAIWSLVIC
MNIMGGALIL VSFI
