NU2M_MYXGL
ID NU2M_MYXGL Reviewed; 348 AA.
AC O21078; O63918;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS Myxine glutinosa (Atlantic hagfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC Myxiniformes; Myxinidae; Myxininae; Myxine.
OX NCBI_TaxID=7769;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9254918; DOI=10.1093/oxfordjournals.molbev.a025821;
RA Delarbre C., Barriel V., Tillier S., Janvier P., Gachelin G.;
RT "The main features of the craniate mitochondrial DNA between the ND1 and
RT the COI genes were established in the common ancestor with the lancelet.";
RL Mol. Biol. Evol. 14:807-813(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9541532; DOI=10.1007/pl00006317;
RA Rasmussen A.S., Janke A., Arnason U.;
RT "The mitochondrial DNA molecule of the hagfish (Myxine glutinosa) and
RT vertebrate phylogeny.";
RL J. Mol. Evol. 46:382-388(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11677623; DOI=10.1007/s002390010250;
RA Delarbre C., Rasmussen A.S., Arnason U., Gachelin G.;
RT "The complete mitochondrial genome of the hagfish Myxine glutinosa: unique
RT features of the control region.";
RL J. Mol. Evol. 53:634-641(2001).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; Y09527; CAA70717.1; -; Genomic_DNA.
DR EMBL; Y15187; CAA75486.1; -; Genomic_DNA.
DR EMBL; AJ404477; CAC20650.1; -; Genomic_DNA.
DR PIR; T13817; T13817.
DR RefSeq; NP_073274.1; NC_002639.1.
DR AlphaFoldDB; O21078; -.
DR SMR; O21078; -.
DR GeneID; 802344; -.
DR CTD; 4536; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..348
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117610"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 205
FT /note="I -> V (in Ref. 2; CAA75486)"
FT /evidence="ECO:0000305"
FT CONFLICT 315
FT /note="S -> C (in Ref. 2; CAA75486)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 38789 MW; DD123DADD1CF61EA CRC64;
MMTLILILGI FLGTMTTMFS SSWFFAWLGL EINMMAIIPM MLFPLSQRAL ESSMKYFISQ
AVASSTIILA SSWNYFSSGQ WTISFMSDNL AITLIILALL LKLGLAPLHF WLPEVLQGVN
LHMGLIISTW QKLAPLTLLI QVSSNLNNMY ILISISVMSV LAGGFGGLNQ TQLRKLLAYS
SISHMGWIVG VMAVSASLSW VTTVIYLIIN FSIFTILIEL NSTKISDLML SWSKTSWSHT
KCILVLLSLG GLPPFTGFFL KLSISNALIS NSLILMTILL MAGSLISLFF YLRLSFMTAL
LLAPTNLQIK GTWKSPHYSN LLFNLMFLFS ILLLPLSPFM ISLFQISW
