位置:首页 > 蛋白库 > NU2M_PANTR
NU2M_PANTR
ID   NU2M_PANTR              Reviewed;         347 AA.
AC   O21798; Q9T9W2;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000250|UniProtKB:P03891};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03891};
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2 {ECO:0000250|UniProtKB:P03891}; Synonyms=MTND2, NADH2, ND2;
OS   Pan troglodytes (Chimpanzee).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-94.
RX   PubMed=9475751; DOI=10.1093/genetics/148.1.409;
RA   Wise C.A., Sraml M., Easteal S.;
RT   "Departure from neutrality at the mitochondrial NADH dehydrogenase subunit
RT   2 gene in humans, but not in chimpanzees.";
RL   Genetics 148:409-421(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-94.
RX   PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA   Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT   "Recent African origin of modern humans revealed by complete sequences of
RT   hominoid mitochondrial DNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity and assembly of complex
CC       I. {ECO:0000250|UniProtKB:P03891}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03891};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits. Interacts with TMEM242
CC       (By similarity). {ECO:0000250|UniProtKB:P03891,
CC       ECO:0000250|UniProtKB:P03892}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF014908; AAC25467.1; -; Genomic_DNA.
DR   EMBL; AF014909; AAC25468.1; -; Genomic_DNA.
DR   EMBL; AF014910; AAC25469.1; -; Genomic_DNA.
DR   EMBL; AF014911; AAC25470.1; -; Genomic_DNA.
DR   EMBL; AF014912; AAC25471.1; -; Genomic_DNA.
DR   EMBL; AF014913; AAC25472.1; -; Genomic_DNA.
DR   EMBL; AF014914; AAC25473.1; -; Genomic_DNA.
DR   EMBL; AF014915; AAC25474.1; -; Genomic_DNA.
DR   EMBL; AF014916; AAC25475.1; -; Genomic_DNA.
DR   EMBL; AF014917; AAC25476.1; -; Genomic_DNA.
DR   EMBL; AF014918; AAC25477.1; -; Genomic_DNA.
DR   EMBL; AF014919; AAC25478.1; -; Genomic_DNA.
DR   EMBL; AF014920; AAC25479.1; -; Genomic_DNA.
DR   EMBL; AF014921; AAC25480.1; -; Genomic_DNA.
DR   EMBL; D38113; BAA85269.1; -; Genomic_DNA.
DR   RefSeq; NP_008187.1; NC_001643.1.
DR   AlphaFoldDB; O21798; -.
DR   SMR; O21798; -.
DR   STRING; 9598.ENSPTRP00000061406; -.
DR   PaxDb; O21798; -.
DR   GeneID; 807865; -.
DR   KEGG; ptr:807865; -.
DR   CTD; 4536; -.
DR   eggNOG; KOG4668; Eukaryota.
DR   InParanoid; O21798; -.
DR   OrthoDB; 1153818at2759; -.
DR   Proteomes; UP000002277; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..347
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117617"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         94
FT                   /note="P -> S (in strain: Isolate A-292)"
FT                   /evidence="ECO:0000269|PubMed:7530363,
FT                   ECO:0000269|PubMed:9475751"
FT                   /id="VAR_018716"
FT   CONFLICT        14
FT                   /note="F -> L (in Ref. 2; BAA85269)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        57
FT                   /note="T -> I (in Ref. 2; AAC25469/AAC25472/AAC25476/
FT                   AAC25479/BAA85269)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   347 AA;  39020 MW;  2E8269D105810D4E CRC64;
     MNPLAQPIIY STIFTGTLIT ALSSHWFFTW VGLEMNMLAF IPILTKKMSP RSTEAATKYF
     LTQATASMIL LMAILSNSML SGQWTMTNTT NQYPSLMIMM AMAMKLGMAP FHFWVPEVTQ
     GTPLMSGLLL LTWQKLAPIS IMYQISSSLN VNLLLTLSIL SIMAGSWGGL NQTQLRKILA
     YSSITHMGWM MAVLPYNPNM TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL
     TPLIPSTLLS LGGLPPLTGF LPKWVIIEEF TKNNSLIIPT IMAIITLLNL YFYLRLIYST
     SITLLPMSNN VKMKWQFEHT KPTPFLPTLI TLTTLLLPIS PFMLMIL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024