NU2M_PARLI
ID NU2M_PARLI Reviewed; 352 AA.
AC P12771;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2;
OS Paracentrotus lividus (Common sea urchin).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinidae; Paracentrotus.
OX NCBI_TaxID=7656;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2544576; DOI=10.1016/s0021-9258(18)60413-2;
RA Cantatore P., Roberti M., Rainaldi G., Gadaleta M.N., Saccone C.;
RT "The complete nucleotide sequence, gene organization, and genetic code of
RT the mitochondrial genome of Paracentrotus lividus.";
RL J. Biol. Chem. 264:10965-10975(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-263.
RX PubMed=3596250; DOI=10.1016/0378-1119(87)90091-6;
RA Cantatore P., Roberti M., Morisco P., Rainaldi G., Gadaleta M.N.,
RA Saccone C.;
RT "A novel gene order in the Paracentrotus lividus mitochondrial genome.";
RL Gene 53:41-54(1987).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; J04815; AAA68134.1; -; Genomic_DNA.
DR EMBL; M16517; AAA31988.2; -; Genomic_DNA.
DR PIR; B34284; B34284.
DR RefSeq; NP_008122.1; NC_001572.1.
DR AlphaFoldDB; P12771; -.
DR SMR; P12771; -.
DR GeneID; 807709; -.
DR CTD; 4536; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..352
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117620"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 352 AA; 39010 MW; 5BE9023550B65B9A CRC64;
MHQMISIFLF LTVVSGTIIV VSAENWFVIW LGLELSTLAL IPILWFCFTP RNIEATIKYF
LVQAFSAALL LNSALIQAWF SGSWSALIPM ESFPSLCLSV ALAFNLGLAA CHFWLPDVLQ
GLPFIQGLII ATWQKIAPLF LLFYFNQLNF SYFIILAALI SILVGGWGGL NQTQTRKILA
FSSIGNMGWI VVTSAFSLGT AAMMLFIYLV INTSIFLILD FLSIFTLGHL NNTSQLSPIS
ITLVILTILS LGGLPPLTGF ILKFSSLYSL INNGFIFFSS VMIIGSLLSL FFYLRIAFNT
TLILFPQHLI SLTAWRNSTE AEPLMAKTWL VSSFSVLSIL AIPLTIPLYI NV