NU2M_PIG
ID NU2M_PIG Reviewed; 347 AA.
AC O79875;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2 {ECO:0000250|UniProtKB:P03891};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03891};
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=MT-ND2 {ECO:0000250|UniProtKB:P03891}; Synonyms=MTND2, NADH2, ND2;
OS Sus scrofa (Pig).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9732457; DOI=10.1007/pl00006388;
RA Ursing B.M., Arnason U.;
RT "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL J. Mol. Evol. 47:302-306(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Landrace;
RX PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA Mao S.J.T., Huang M.C.;
RT "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT dating evolutionary divergence within artiodactyla.";
RL Gene 236:107-114(1999).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03891}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03891};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM242
CC (By similarity). {ECO:0000250|UniProtKB:P03891,
CC ECO:0000250|UniProtKB:P03892}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03892}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; AJ002189; CAA05230.1; -; Genomic_DNA.
DR EMBL; AF034253; AAD34186.1; -; Genomic_DNA.
DR PIR; T10973; T10973.
DR RefSeq; NP_008635.1; NC_000845.1.
DR PDB; 5GPN; EM; 5.40 A; f=1-347.
DR PDB; 5GUP; EM; 4.00 A; i=1-347.
DR PDB; 7V2C; EM; 2.90 A; i=1-347.
DR PDB; 7V2D; EM; 3.30 A; i=1-347.
DR PDB; 7V2E; EM; 2.80 A; i=1-347.
DR PDB; 7V2F; EM; 3.10 A; i=1-347.
DR PDB; 7V2H; EM; 2.50 A; i=1-347.
DR PDB; 7V2K; EM; 2.70 A; i=1-347.
DR PDB; 7V2R; EM; 2.60 A; i=1-347.
DR PDB; 7V30; EM; 2.70 A; i=1-347.
DR PDB; 7V31; EM; 2.90 A; i=1-347.
DR PDB; 7V32; EM; 3.20 A; i=1-347.
DR PDB; 7V33; EM; 2.60 A; i=1-347.
DR PDB; 7V3M; EM; 2.90 A; i=1-347.
DR PDB; 7VBL; EM; 2.60 A; i=1-347.
DR PDB; 7VBP; EM; 2.80 A; i=1-347.
DR PDB; 7VC0; EM; 2.60 A; i=1-347.
DR PDB; 7VWL; EM; 2.70 A; i=1-347.
DR PDBsum; 5GPN; -.
DR PDBsum; 5GUP; -.
DR PDBsum; 7V2C; -.
DR PDBsum; 7V2D; -.
DR PDBsum; 7V2E; -.
DR PDBsum; 7V2F; -.
DR PDBsum; 7V2H; -.
DR PDBsum; 7V2K; -.
DR PDBsum; 7V2R; -.
DR PDBsum; 7V30; -.
DR PDBsum; 7V31; -.
DR PDBsum; 7V32; -.
DR PDBsum; 7V33; -.
DR PDBsum; 7V3M; -.
DR PDBsum; 7VBL; -.
DR PDBsum; 7VBP; -.
DR PDBsum; 7VC0; -.
DR PDBsum; 7VWL; -.
DR AlphaFoldDB; O79875; -.
DR SMR; O79875; -.
DR STRING; 9823.ENSSSCP00000019136; -.
DR PaxDb; O79875; -.
DR PeptideAtlas; O79875; -.
DR PRIDE; O79875; -.
DR Ensembl; ENSSSCT00000019664; ENSSSCP00000019136; ENSSSCG00000018069.
DR Ensembl; ENSSSCT00070061666; ENSSSCP00070052579; ENSSSCG00070030629.
DR GeneID; 808502; -.
DR KEGG; ssc:808502; -.
DR CTD; 4536; -.
DR eggNOG; KOG4668; Eukaryota.
DR GeneTree; ENSGT00730000111348; -.
DR InParanoid; O79875; -.
DR OMA; HFWVPEV; -.
DR OrthoDB; 1153818at2759; -.
DR Proteomes; UP000008227; Mitochondrion.
DR Proteomes; UP000314985; Mitochondrion.
DR Bgee; ENSSSCG00000018069; Expressed in hypothalamus and 45 other tissues.
DR ExpressionAtlas; O79875; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..347
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117625"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 347 AA; 39056 MW; 98FBE1D9D0E30D43 CRC64;
MNPIIYTTLI MTVMSGTMLV MISSHWLLIW IGFEMNLLAM IPVLMKNFNP RATEAATKYF
LTQATASMML MMAIIINLLY SGQWTITKMF NPVAMTMMTM ALAMKLGLSP FHFWVPEVTQ
GISLQAGLLL LTWQKLAPLS VLCQISQSIN PNLMLTMAML SILIGGWGGL NQTQLRKIMA
YSSIAHMGWM TAVLPYNTTM TILNLLIYIT MTLAMFMLLI HSSATTTLSL SHTWNKMPVI
TSLMMVTLLS MGGLPPLSGF MPKWMIIQEM TKNESIIMPT LMAMTALLNL YFYMRLAYSS
SLTMFPSTNN MKMKWQFEHT KQMKLLPTMI VLSTLVLPMT PALSSLN
