NU2M_PISOC
ID NU2M_PISOC Reviewed; 353 AA.
AC P24996;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2;
OS Pisaster ochraceus (Ochre sea star) (Asterias ochracea).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC Forcipulatacea; Forcipulatida; Asteriidae; Pisaster.
OX NCBI_TaxID=7612;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1976816; DOI=10.1007/bf02109496;
RA Smith M.J., Banfield D.K., Doteval K., Gorski S., Kowbel D.J.;
RT "Nucleotide sequence of nine protein-coding genes and 22 tRNAs in the
RT mitochondrial DNA of the sea star Pisaster ochraceus.";
RL J. Mol. Evol. 31:195-204(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; X55514; CAA39122.1; -; Genomic_DNA.
DR PIR; S14203; S14203.
DR AlphaFoldDB; P24996; -.
DR SMR; P24996; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..353
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117626"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 353 AA; 38771 MW; 092AE66053282D7E CRC64;
MNRSVVLILL LNIIVSVVIV LSSHSWFSVC DGLELNTLSV LPILCGQFSP RGVESTIKYF
LVQAFSAAMI LNVALVQLWL CSSWSVSCPL NSFSSIVLTL ALCLKLGLFP CHFWFPDVLQ
GLSFLQGLLL STWQKVAPFI ILVSVCNIIS INVLTTLGCL SVLVGGWGGL NQSQVRKIMA
FSSISHLGWI CSVLSYSIYV GCIMFVVYIV LSSTVFLINN EGNLYNLSSL ARLVYCNNVM
GNVLVLVILS LGGLPPLTGF LNKFIALECL LSNNLLVPCA ILIVGSLLSL FFYLRISFNS
VLCLFPQHSM MLFSWRNVSG YYGNTSFYTV LLSILSSMSI LGLLLVPALW SYH