ID   NU2M_POLOR              Reviewed;         345 AA.
AC   Q95910;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS   Polypterus ornatipinnis (Ornate bichir).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX   NCBI_TaxID=49895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8913758; DOI=10.1093/genetics/144.3.1165;
RA   Noack K., Zardoya R., Meyer A.;
RT   "The complete mitochondrial DNA sequence of the bichir (Polypterus
RT   ornatipinnis), a basal ray-finned fish: ancient establishment of the
RT   consensus vertebrate gene order.";
RL   Genetics 144:1165-1180(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; U62532; AAC60306.1; -; Genomic_DNA.
DR   PIR; T11455; T11455.
DR   RefSeq; NP_008317.1; NC_001778.1.
DR   AlphaFoldDB; Q95910; -.
DR   SMR; Q95910; -.
DR   GeneID; 808037; -.
DR   CTD; 4536; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..345
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117628"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   345 AA;  38192 MW;  682F49DF138E2E97 CRC64;
     MNPYILSIML ISLGLGTTLT FASSNWLLAW MGLEINTLAI IPLMANNHHP RAVEAATKYF
     ITQAAAAALL LFSSLINAWQ SGQWMIQDMS MPMSALMTIA IAIKLGVAPV HFWLPEVMQG
     IKLNTGLILA TWQKLAPLAL LYQISNNLMP ELMIALGLMS TIVGGWGGLN QTQIRKIMAY
     SSIAHLGWII SIMHFMPSLA IINLIMYIIM TTTMFMIFNT LNSTTINALA INWSKFPALS
     AITMLALLSL GGLPPLSGFL PKWLILQELT NQNLALTATV MALSALLSLY FYLRLSYSLT
     TTIMPNTYQH MLNWNIKTKI TFILPTMMIM TIAMLPISPS IISMF