ID   NU2M_RHISA              Reviewed;         313 AA.
AC   O99817;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=ND2;
OS   Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Rhipicephalus.
OX   NCBI_TaxID=34632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9866211; DOI=10.1093/oxfordjournals.molbev.a025903;
RA   Black W.C. IV, Roehrdanz R.L.;
RT   "Mitochondrial gene order is not conserved in arthropods: prostriate and
RT   metastriate tick mitochondrial genomes.";
RL   Mol. Biol. Evol. 15:1772-1785(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; AF081829; AAD05517.1; -; Genomic_DNA.
DR   PIR; T11153; T11153.
DR   RefSeq; NP_008510.1; NC_002074.1.
DR   AlphaFoldDB; O99817; -.
DR   SMR; O99817; -.
DR   EnsemblMetazoa; GeneID_808361_df_mr; NP_008510.1; GeneID_808361.
DR   GeneID; 808361; -.
DR   KEGG; rsan:808361; -.
DR   CTD; 4536; -.
DR   VEuPathDB; VectorBase:GeneID_808361; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..313
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117634"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  37099 MW;  E6382AEDAF32B0B6 CRC64;
     MMIWIITISI LVSLSSNSWF IFWLMMEINM MSFIPIMNDF KMKNYNSMIT YFIIQSFSSS
     LFFISSFQYS LFNMELFFSL INISVLIKLG MIPFHFWLIM ISESLTFYSL LILLTIQKII
     PLLIIEKFMN SLMIPLFIMS SLLASIMAMK YKLIKQILIF SSISHQGWIL CLIAKKMNFW
     VSYLMLYSII IYSIIINCKE MNFNKLCDLT KKKISSKMKN TMIMSMMSLA GMPPFIGFFM
     KIMAIFFLMK MNLIFMMILI ISSLINLFFY LRILTPLFFI NSKFSIWSFN NMKSNFMIKI
     NMLLLIILIN IFF