ID   NU2M_STRCA              Reviewed;         346 AA.
AC   O21398; O79100;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 2;
GN   Name=MT-ND2; Synonyms=MTND2, NADH2, ND2;
OS   Struthio camelus (Common ostrich).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9214748; DOI=10.1093/oxfordjournals.molbev.a025815;
RA   Harlid A., Janke A., Arnason U.;
RT   "The mtDNA sequence of the ostrich and the divergence between paleognathous
RT   and neognathous birds.";
RL   Mol. Biol. Evol. 14:754-761(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.;
RT   "Primers for a PCR-based approach to complete mitochondrial genome
RT   sequencing.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11370967; DOI=10.1098/rspb.2001.1587;
RA   Haddrath O., Baker A.J.;
RT   "Complete mitochondrial DNA genome sequences of extinct birds: ratite
RT   phylogenetics and the vicariance biogeography hypothesis.";
RL   Proc. R. Soc. B 268:939-945(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR   EMBL; Y12025; CAA72745.1; -; Genomic_DNA.
DR   EMBL; AF069429; AAD09384.1; -; Genomic_DNA.
DR   EMBL; AF338715; AAK53352.1; -; Genomic_DNA.
DR   PIR; B90612; B90612.
DR   PIR; T12410; T12410.
DR   RefSeq; NP_115442.1; NC_002785.1.
DR   AlphaFoldDB; O21398; -.
DR   SMR; O21398; -.
DR   GeneID; 803269; -.
DR   CTD; 4536; -.
DR   OrthoDB; 1153818at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   InterPro; IPR010933; NADH_DH_su2_C.
DR   InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF06444; NADH_dehy_S2_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01436; NADHDHGNASE2.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..346
FT                   /note="NADH-ubiquinone oxidoreductase chain 2"
FT                   /id="PRO_0000117640"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        213
FT                   /note="A -> T (in Ref. 1; CAA72745)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   346 AA;  37737 MW;  539FF34CAE03AAB1 CRC64;
     MNPHAKLISL ISLLLGTTIT ISSNHWIMAW TGLEINTLAI IPLISKSHHP RAVEASVKYF
     LVQAAASALV LFSSMSNAWA TGQWDITQLT HPTASMLLTA AIAIKLGLVP FHFWFPEVLQ
     GTSLTTALLL STLMKLPPMA ILLMTSPSLN PTVLTSMALA SAALGGWMGL NQTQTRKILA
     FSSIAHLGWM TMIIIYNPKL TLLTFYLYIL MTATVFLSLN TTKTLKLSTL MTSWTKAPVL
     NAALMLTLLS LAGLPPLTGF MPKWLILQEL TKQEMTTVAT IIALLSLLGL FFYLRLAYYA
     TITLPPNSAN HMKQWYISNP TNTSIAILSS LSAILLPISP MILAAL