NU2M_STRPU
ID NU2M_STRPU Reviewed; 352 AA.
AC P15549;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 2;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 2;
GN Name=ND2;
OS Strongylocentrotus purpuratus (Purple sea urchin).
OG Mitochondrion.
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3172215; DOI=10.1016/0022-2836(88)90452-4;
RA Jacobs H.T., Elliott D.J., Math V.B., Farquharson A.;
RT "Nucleotide sequence and gene organization of sea urchin mitochondrial
RT DNA.";
RL J. Mol. Biol. 202:185-217(1988).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the complex I subunit 2 family. {ECO:0000305}.
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DR EMBL; X12631; CAA31152.1; -; Genomic_DNA.
DR PIR; S01500; S01500.
DR RefSeq; NP_006966.1; NC_001453.1.
DR AlphaFoldDB; P15549; -.
DR SMR; P15549; -.
DR EnsemblMetazoa; GeneID_2652717_df_mr; NP_006966; GeneID_2652717.
DR GeneID; 2652717; -.
DR KEGG; spu:2652717; -.
DR CTD; 4536; -.
DR InParanoid; P15549; -.
DR OMA; HFWVPEV; -.
DR OrthoDB; 1153818at2759; -.
DR PhylomeDB; P15549; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR InterPro; IPR010933; NADH_DH_su2_C.
DR InterPro; IPR003917; NADH_UbQ_OxRdtase_chain2.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF06444; NADH_dehy_S2_C; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01436; NADHDHGNASE2.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..352
FT /note="NADH-ubiquinone oxidoreductase chain 2"
FT /id="PRO_0000117641"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 352 AA; 38653 MW; 3C44E423AEC81019 CRC64;
MRQIVSTFLF VTVVSGTIIV VSSENWFIIW VGLELSTLAL VPILCSGFSP RNVEADNKYF
LVQASSAALL LNGALGQAWL TGSWSILDPV NEVTSICLSI ALAFKIGLAP VHFWFPDVLQ
GLPFFQGLII ATWQKIAPLI LMFYFSQLGF SYLLITPSLI SVLIGGWGGL NQTQVRKILA
FSSIGNMGWL VITSAYSFNA AIIMLVIYLI INTSLFLLFD HLKVSTLGHL NTISQLSPIS
VALVLLVMLS LGGLPPLTGF ILKFTSLYFL VANNFIILSS IMIIGNLQDY FFYLRISFNT
SLFLFPQHII SSASWRNSTI ISPLAPKAWL SSVSTVLSTL AIPLTLPLYI IT