NU301_CAEEL
ID NU301_CAEEL Reviewed; 2194 AA.
AC Q6BER5; B1Q274; O45407; O45409; O45410; Q5WRM3; Q95ZU8; Q9NLC1;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Nucleosome-remodeling factor subunit NURF301-like;
GN Name=nurf-1; ORFNames=F26H11.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND SUBUNIT.
RX PubMed=16774993; DOI=10.1242/dev.02444;
RA Andersen E.C., Lu X., Horvitz H.R.;
RT "C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the
RT determination of multiple cell fates.";
RL Development 133:2695-2704(2006).
CC -!- FUNCTION: Histone-binding component of a NURF-like (nucleosome
CC remodeling factor-like) complex, which would catalyze ATP-dependent
CC nucleosome sliding and facilitate transcription of chromatin
CC (Probable). Involved in vulval cell fates.
CC {ECO:0000269|PubMed:16774993, ECO:0000305}.
CC -!- SUBUNIT: Part of a nucleosome remodeling factor-like (NURF-like)
CC complex containing nurf-1 and isw-1. {ECO:0000305|PubMed:16774993}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=c;
CC IsoId=Q6BER5-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q6BER5-3; Sequence=VSP_044204;
CC Name=b;
CC IsoId=Q6BER5-2; Sequence=VSP_020415, VSP_020418;
CC Name=d;
CC IsoId=Q6BER5-4; Sequence=VSP_020413;
CC Name=e;
CC IsoId=Q6BER5-5; Sequence=VSP_020410, VSP_020421;
CC Name=f;
CC IsoId=Q6BER5-6; Sequence=VSP_020411, VSP_020420;
CC Name=g;
CC IsoId=Q6BER5-7; Sequence=VSP_020412, VSP_020419;
CC Name=h;
CC IsoId=Q6BER5-8; Sequence=VSP_020413, VSP_035030;
CC -!- SIMILARITY: Belongs to the BPTF family. {ECO:0000305}.
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DR EMBL; Z81515; CAB04195.1; -; Genomic_DNA.
DR EMBL; Z81515; CAB04197.3; -; Genomic_DNA.
DR EMBL; Z81515; CAB04198.1; -; Genomic_DNA.
DR EMBL; Z81515; CAB54234.4; -; Genomic_DNA.
DR EMBL; Z81515; CAC42289.3; -; Genomic_DNA.
DR EMBL; Z81515; CAH04722.2; -; Genomic_DNA.
DR EMBL; Z81515; CAH60782.1; -; Genomic_DNA.
DR EMBL; Z81515; CAQ16138.1; -; Genomic_DNA.
DR PIR; T21430; T21430.
DR PIR; T21432; T21432.
DR PIR; T21433; T21433.
DR PIR; T21435; T21435.
DR RefSeq; NP_001022117.2; NM_001026946.3. [Q6BER5-1]
DR RefSeq; NP_001022118.2; NM_001026947.5.
DR RefSeq; NP_001022119.1; NM_001026948.3. [Q6BER5-5]
DR RefSeq; NP_001022120.1; NM_001026949.3. [Q6BER5-6]
DR RefSeq; NP_001022121.1; NM_001026950.3.
DR RefSeq; NP_001122607.1; NM_001129135.2.
DR RefSeq; NP_496994.3; NM_064593.3. [Q6BER5-2]
DR RefSeq; NP_496995.3; NM_064594.6. [Q6BER5-3]
DR AlphaFoldDB; Q6BER5; -.
DR SMR; Q6BER5; -.
DR BioGRID; 40379; 13.
DR DIP; DIP-25937N; -.
DR IntAct; Q6BER5; 8.
DR STRING; 6239.F26H11.2a; -.
DR EPD; Q6BER5; -.
DR PaxDb; Q6BER5; -.
DR PeptideAtlas; Q6BER5; -.
DR EnsemblMetazoa; F26H11.2a.1; F26H11.2a.1; WBGene00009180. [Q6BER5-3]
DR EnsemblMetazoa; F26H11.2b.1; F26H11.2b.1; WBGene00009180. [Q6BER5-2]
DR EnsemblMetazoa; F26H11.2c.1; F26H11.2c.1; WBGene00009180. [Q6BER5-1]
DR EnsemblMetazoa; F26H11.2d.1; F26H11.2d.1; WBGene00009180. [Q6BER5-4]
DR EnsemblMetazoa; F26H11.2d.2; F26H11.2d.2; WBGene00009180. [Q6BER5-4]
DR EnsemblMetazoa; F26H11.2e.1; F26H11.2e.1; WBGene00009180. [Q6BER5-5]
DR EnsemblMetazoa; F26H11.2f.1; F26H11.2f.1; WBGene00009180. [Q6BER5-6]
DR GeneID; 175098; -.
DR UCSC; F26H11.2a; c. elegans.
DR CTD; 175098; -.
DR WormBase; F26H11.2a; CE46896; WBGene00009180; nurf-1. [Q6BER5-3]
DR WormBase; F26H11.2b; CE46841; WBGene00009180; nurf-1. [Q6BER5-2]
DR WormBase; F26H11.2c; CE47064; WBGene00009180; nurf-1. [Q6BER5-1]
DR WormBase; F26H11.2d; CE42388; WBGene00009180; nurf-1. [Q6BER5-4]
DR WormBase; F26H11.2e; CE15909; WBGene00009180; nurf-1. [Q6BER5-5]
DR WormBase; F26H11.2f; CE15910; WBGene00009180; nurf-1. [Q6BER5-6]
DR WormBase; F26H11.2g; CE37638; WBGene00009180; nurf-1. [Q6BER5-7]
DR WormBase; F26H11.2h; CE42387; WBGene00009180; nurf-1. [Q6BER5-8]
DR eggNOG; KOG1473; Eukaryota.
DR eggNOG; KOG1632; Eukaryota.
DR HOGENOM; CLU_000284_0_0_1; -.
DR InParanoid; Q6BER5; -.
DR OMA; DEEQTHY; -.
DR OrthoDB; 180712at2759; -.
DR SignaLink; Q6BER5; -.
DR PRO; PR:Q6BER5; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00009180; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q6BER5; baseline and differential.
DR GO; GO:0016589; C:NURF complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.20.920.10; -; 1.
DR Gene3D; 3.30.40.10; -; 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; PTHR45975; 2.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; SSF47370; 1.
DR SUPFAM; SSF57903; SSF57903; 3.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 3.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Bromodomain; Chromatin regulator; Coiled coil;
KW Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..2194
FT /note="Nucleosome-remodeling factor subunit NURF301-like"
FT /id="PRO_0000249321"
FT DOMAIN 196..256
FT /note="DDT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT DOMAIN 341..396
FT /note="DDT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT DOMAIN 1883..1953
FT /note="DDT 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT DOMAIN 1948..2014
FT /note="DDT 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT DOMAIN 2047..2117
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT ZN_FING 347..392
FT /note="PHD-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 1899..1950
FT /note="PHD-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 1959..2010
FT /note="PHD-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1158..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1151..1187
FT /evidence="ECO:0000255"
FT COMPBIAS 60..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..137
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1666..1701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1847..1878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1789
FT /note="Missing (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_020410"
FT VAR_SEQ 1..1676
FT /note="Missing (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_020411"
FT VAR_SEQ 1..1626
FT /note="Missing (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_020412"
FT VAR_SEQ 1..1386
FT /note="Missing (in isoform d and isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_020413"
FT VAR_SEQ 1594..1621
FT /note="EHRRLLAGRQKQKVTTYRDFMASRGYLD -> FQAHYDMPDDATGFAVSTTT
FT EQVPDEQQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020415"
FT VAR_SEQ 1622..2194
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020418"
FT VAR_SEQ 1627..1875
FT /note="MQTKPTFLPFEFNEEEEREINEAIAREEAWMRQEEENKTSGYDSSGNPIRSI
FT TSSGDTQRAPPYVSNLLPSSNDSPDDKVIKQVLDVMFSQVCRWDRQYGWSKTHVKRARQ
FT KNDSDKMHLRKFRMNQRELLITDHMERLKKEINKRRTRMENEAEQQCGLLTPWRKARAR
FT PHRAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSRRRRTSANLSKSED
FT DRDKPESQSTAPKSKERRTS -> MVLRTVILPTATYTAPSQYCPSTVLSNLTLSCPYQ
FT DQEADASLEISDFAEVLPKFESAEQDWNSFGYLLNEQPGTSSDKTTTPIKKITVFQKPV
FT (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_020419"
FT VAR_SEQ 1677..1799
FT /note="SITSSGDTQRAPPYVSNLLPSSNDSPDDKVIKQVLDVMFSQVCRWDRQYGWS
FT KTHVKRARQKNDSDKMHLRKFRMNQRELLITDHMERLKKEINKRRTRMENEAEQQCGLL
FT TPWRKARARPHR -> MVLRTVILPTATYTAPSQYCPSTVLSNLTLSCPYQDQEADASL
FT EISDFAEVLPKFESAEQDWNSFGYLLNEQPGTSSDKTTTPIKKITVFQKPVEPIGKGPR
FT RRRRCADREISEL (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_020420"
FT VAR_SEQ 1745
FT /note="H -> QMFS (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_044204"
FT VAR_SEQ 1790..1799
FT /note="WRKARARPHR -> MKALHVFFLP (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_020421"
FT VAR_SEQ 1832..2085
FT /note="Missing (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_035030"
SQ SEQUENCE 2194 AA; 252195 MW; 1A85C3AB3704E93B CRC64;
MAPPRGRSKR KHPSESGNSS IADSEDPSES TSSSRPRRSR LPKRYFDDGY SPPPTKKRAA
QRETPSDAEE VEVKIEEISV RSTPASTPAP KSTSKARGRP KKNPTPPRRK SLKRQEEDII
YMDEDSEEEE ESSDDEFMLN EDQVVQEEEE ELNLTDIKIE KGLDEENKYC PWLDEDPASL
PKLELPESSQ DIPIPTASIM DAVEIYEILR SYHRTLRITP FTFEDFCAAL ISHNNSCIMA
EVHMALLRNC LKSDDEEQTH YSVTETNNSV NIMIHHMDTL TYAEILRQYI EAYPFADASV
RDAINVDNYP FVGYDAKLVV LLFMSYRFLY SSEFKKLVNN VGKFQNDENC RVCGKSSGRV
VGCTQCEAAF HVECSHLKPF PEVLVCNICK KNSAVRGVLP PDEAVDREPL RSQPIGRDRY
GRYYWFIVRR LVVQSLDETE LYYYSTVPQL YQLLQKLDRT YYEKDLCDTI RLRIDEFLEQ
MALTVEMTSE RREAALETMV KRQLIGYDFA EATTPQIYLH RDSMKRMASI LRDCAQKGQV
KQEVKLEEPV EGQSPVKCVQ FVEDSILPES MIGIFDAKLI NTFWSGGATQ EELVEQFVDI
SDNFDAPSAN LWRMGDEGND QTFMTYYNYY SRNEMSESFL TRKKAADKKK YMASKFAQID
NFDWVVAKNR QFYGDASLHC KFIMWTLQQV IKNIPIDLMH RKWPEFAKGF DLEVSVADDY
KKLVTCLLKL DCAVRKTIFM PQWWNGLGQT RLERITVDQR ENFMKEQQRL KKIDADALTK
DLDDSFVRVN YMKPKWPNTY ILRQRGETYR NAGKGSMGGW AWVAAKYVEK WIQVPESPKL
PLAVTVEEIK TESVSNRKAR RLELLVSKIT KKRQRSGGKS SKKPTFELTN GCYSPSCRSN
PNRKCYSPMC RNGYLVSAKQ AHDERKLEES GVLGEEKAWP IPEIQTFSTK RGGKSIFVLQ
KKILRQMIMG GGCQQVYMPG FSAGIKSNLL IWPYPAPRPT LDLCWKWQTL NARSLHAVAL
QLKIIWSSIK FNEFDPDDTH PDRRVVIDTP SHDERRRIIR HKEMPPYGQY ERYEMEIEII
PLYDEPEEED ESWLSRNRGG SSEFSHRSSS ARKKRPQRSL DNRRATAIRR EWVDGVTLKV
FEIKDYWKWI RAEAEKTAKR KLEATRKAQK AKEDEERRRI QQQQQRSVAR IPVPMHSLIP
SERNNVPYLG SQQQRRPNGN ERGFLEKYNN SSSVSPQAHG YASTPPPGYH QPQPNIIRQA
GYNQLPRKPT TSPFNFQSRP VATIPTTPQL RAAAGADGVV RAVMMTPGNK STVNTNSTPY
PQALNRQQYQ LQRQQQQPAV RRLTNGYHFM DGTMRGGGRN PSVQMHQRLP QNRAALQRPF
GESTTEMRRV TEAAIPDNDG DEQPPVIPRY DPTSNFDAQR AQQQHPQSRP VYSTPAQMIR
TTQPGGVKHN VILMKASDGT QKMVLKPGQF PPGTVISTGQ RVVPYRQPTA VQQRQLYTAT
PGTRVVRIPN ANGGAPRQQD HQVMRRVVQA SGPRAMEYMD DQGTPPPGQQ VRYVLQGGNS
GTPNVNPPKV SSRGGPRGGL TMQMVQQQQQ HNPEHRRLLA GRQKQKVTTY RDFMASRGYL
DTSKFMMQTK PTFLPFEFNE EEEREINEAI AREEAWMRQE EENKTSGYDS SGNPIRSITS
SGDTQRAPPY VSNLLPSSND SPDDKVIKQV LDVMFSQVCR WDRQYGWSKT HVKRARQKND
SDKMHLRKFR MNQRELLITD HMERLKKEIN KRRTRMENEA EQQCGLLTPW RKARARPHRA
AKPKAEVKKE VINPADITLG GDTYDYVKEQ KPTESIATNV SRRRRTSANL SKSEDDRDKP
ESQSTAPKSK ERRTSEPPAS HVAFHTPGSA TPHDINLSIE HCTCQKIFDA SKLYIQCELC
ARWYHGDCVG VAEQTILGLE HWSCEECIEE QERVKDQPAL YCVCQKPYDD TKFYVGCDSC
QGWFHPECVG TTRAEAEQAA DYNCPACTRE AEGYESEASD VSGSSRVSVQ LTRADYTHVF
ELLELLLEHR MSTPFRNPVD LNEFPDYEKF IKKPMDLSTI TKKVERTEYL YLSQFVNDVN
QMFENAKTYN PKGNAVFKCA ETMQEVFDKK LIDVREQMTA RQQMLLLATA QQQDPMSSIR
KRVQSESQRT VDSLDIDSDQ LLPLDANLMR LYDF
