NU3M_ALLMI
ID NU3M_ALLMI Reviewed; 115 AA.
AC O47874;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS Alligator mississippiensis (American alligator).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=9402737; DOI=10.1093/oxfordjournals.molbev.a025736;
RA Janke A., Arnason U.;
RT "The complete mitochondrial genome of Alligator mississippiensis and the
RT separation between recent archosauria (birds and crocodiles).";
RL Mol. Biol. Evol. 14:1266-1272(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sorenson M.D., Dimcheff D.E., Ast J.C., Yuri T., Mindell D.P.;
RT "Primers for a PCR-based approach to complete mitochondrial genome
RT sequencing.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; Y13113; CAA73568.1; -; Genomic_DNA.
DR EMBL; AF069428; AAD09987.1; -; Genomic_DNA.
DR PIR; T11281; T11281.
DR RefSeq; NP_007569.1; NC_001922.1.
DR AlphaFoldDB; O47874; -.
DR SMR; O47874; -.
DR GeneID; 808236; -.
DR KEGG; amj:808236; -.
DR CTD; 4537; -.
DR OrthoDB; 1605459at2759; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117703"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 115 AA; 12946 MW; A27896BAC1EAF54B CRC64;
MNLFIMLTMS SITVSIVVAL NLLTAKTSPD PEKLSPYECG FDPLGSARLP LSIRFFMVGI
LFLLFDLEIA ILLPLTWAIH TLNPLKTITW AIIIFLFLFI GLAYEWLQGG LEWAE
