ID   NU3M_ANOGA              Reviewed;         117 AA.
AC   P34850;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=mt:ND3; Synonyms=ND3;
OS   Anopheles gambiae (African malaria mosquito).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G3;
RX   PubMed=9087549; DOI=10.1111/j.1365-2583.1993.tb00131.x;
RA   Beard C.B., Hamm D.M., Collins F.H.;
RT   "The mitochondrial genome of the mosquito Anopheles gambiae: DNA sequence,
RT   genome organization, and comparisons with mitochondrial sequences of other
RT   insects.";
RL   Insect Mol. Biol. 2:103-124(1993).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; L20934; AAD12196.1; -; Genomic_DNA.
DR   PIR; T09806; T09806.
DR   RefSeq; NP_008075.1; NC_002084.1.
DR   AlphaFoldDB; P34850; -.
DR   SMR; P34850; -.
DR   STRING; 7165.AGAP028373-PA; -.
DR   GeneID; 1267419; -.
DR   KEGG; aga:ND3; -.
DR   CTD; 4537; -.
DR   VEuPathDB; VectorBase:AGAP028373; -.
DR   eggNOG; KOG4662; Eukaryota.
DR   HOGENOM; CLU_119549_3_1_1; -.
DR   InParanoid; P34850; -.
DR   OMA; RFPVKYY; -.
DR   OrthoDB; 1605459at2759; -.
DR   Proteomes; UP000007062; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..117
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117704"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   117 AA;  13630 MW;  4E744A0B30147FC3 CRC64;
     MLMLSTMTLI IFIITIVVMM LATLLSKKTL LDREKCSPFE CGFDPMNSSR LPFSLRFFLI
     AIIFLIFDVE IALLLPMIMI IKTSNLMNWT ITSLFFIFIL LIGLYHEWNQ GALEWNE