ID   NU3M_ARTSA              Reviewed;          70 AA.
AC   P19043;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
DE   Flags: Fragments;
GN   Name=ND3;
OS   Artemia salina (Brine shrimp).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Anostraca; Artemiidae; Artemia.
OX   NCBI_TaxID=85549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3135541; DOI=10.1093/nar/16.14.6515;
RA   Batuecas B., Garesse R., Calleja M., Valverde J.R., Marco R.;
RT   "Genome organization of Artemia mitochondrial DNA.";
RL   Nucleic Acids Res. 16:6515-6529(1988).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; X07664; CAA30511.1; -; Genomic_DNA.
DR   EMBL; X07665; CAA30512.1; -; Genomic_DNA.
DR   AlphaFoldDB; P19043; -.
DR   SMR; P19043; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           <1..>70
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117708"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   NON_CONS        31..32
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         70
SQ   SEQUENCE   70 AA;  8443 MW;  C2D7A01B98AF62D0 CRC64;
     FYYINPREFV NKKVCLDREK SSPFECGFDP LEFLSYPLFI RFFVITLIFL IFDVEIYLLL
     PMVYLNMSSP