NU3M_AVACL
ID NU3M_AVACL Reviewed; 115 AA.
AC A8DQK7; A8DQK3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS Avahi cleesei (Cleese's woolly lemur) (Bemaraha woolly lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Avahi.
OX NCBI_TaxID=402244;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate BEMA12, Isolate BEMA13, Isolate BEMA14, Isolate BEMA8, and
RC Isolate BEMA9;
RA Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E.,
RA Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K.,
RA Brenneman R.A., Louis E.E. Jr.;
RT "Molecular phylogeny and taxonomic revision of the woolly lemurs, genus
RT Avahi (primates: lemuriformes).";
RL Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; DQ856113; ABI54995.1; -; Genomic_DNA.
DR EMBL; DQ856114; ABI54999.1; -; Genomic_DNA.
DR EMBL; DQ856115; ABI55003.1; -; Genomic_DNA.
DR EMBL; DQ856116; ABI55007.1; -; Genomic_DNA.
DR EMBL; DQ856117; ABI55011.1; -; Genomic_DNA.
DR AlphaFoldDB; A8DQK7; -.
DR SMR; A8DQK7; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000323382"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 12
FT /note="A -> V (in strain: Isolate BEMA8)"
SQ SEQUENCE 115 AA; 13044 MW; 3E4B27C37B953C43 CRC64;
MNLSLTLMTD VALALLLVMI AFWLPQLNIY TEKYSSYECG FDPMGSARLP FSMKFFLVAI
TFLLFDLEIA LLLPLPWASQ TTNLKLMLTM ALLLISILAA GLAYEWSQKG LEWEE
