NU3M_BRALA
ID NU3M_BRALA Reviewed; 117 AA.
AC P69237; O47429;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=ND3; Synonyms=NAD3, NADH3;
OS Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomidae; Branchiostoma.
OX NCBI_TaxID=7740;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9628930; DOI=10.1093/nar/26.13.3279;
RA Spruyt N., Delarbre C., Gachelin G., Laudet V.;
RT "Complete sequence of the amphioxus (Branchiostoma lanceolatum)
RT mitochondrial genome: relations to vertebrates.";
RL Nucleic Acids Res. 26:3279-3285(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; Y16474; CAA76254.1; -; Genomic_DNA.
DR PIR; A71391; A71391.
DR RefSeq; NP_007544.1; NC_001912.1.
DR AlphaFoldDB; P69237; -.
DR SMR; P69237; -.
DR GeneID; 808218; -.
DR CTD; 4537; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..117
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117718"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 117 AA; 13268 MW; 8FB4778F167DC11C CRC64;
MLSLTYIVGI ASALVIILLL VGLHLPSVMP DNEKLSAYEC GFDPMGNARL PFSLRFFLVA
ILFLLFDLEI ALILPYPLGV VFSENTFYNY WLVMLLVVVL TFGLMYEWLK GGLEWTE