NU3M_CAEEL
ID NU3M_CAEEL Reviewed; 111 AA.
AC P24895;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=nduo-3 {ECO:0000312|WormBase:MTCE.34};
GN Synonyms=nd3 {ECO:0000312|WormBase:MTCE.34};
GN ORFNames=MTCE.34 {ECO:0000312|WormBase:MTCE.34};
OS Caenorhabditis elegans.
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AB1, AB2, Bristol N2, CB4852, CB4853, CB4854, CB4855, CB4856,
RC CB4857, CB4858, KR314, PB303, PB306, RW7000, and TR403;
RX PubMed=12644560; DOI=10.1093/molbev/msg044;
RA Denver D.R., Morris K., Thomas W.K.;
RT "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and
RT outcrossing.";
RL Mol. Biol. Evol. 20:393-400(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1551572; DOI=10.1093/genetics/130.3.471;
RA Okimoto R., Macfarlane J.L., Clary D.O., Wolstenholme D.R.;
RT "The mitochondrial genomes of two nematodes, Caenorhabditis elegans and
RT Ascaris suum.";
RL Genetics 130:471-498(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
RX PubMed=2235493; DOI=10.1093/nar/18.20.6113;
RA Okimoto R., Macfarlane J.L., Wolstenholme D.R.;
RT "Evidence for the frequent use of TTG as the translation initiation codon
RT of mitochondrial protein genes in the nematodes, Ascaris suum and
RT Caenorhabditis elegans.";
RL Nucleic Acids Res. 18:6113-6118(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; AY171208; AAO16355.1; -; Genomic_DNA.
DR EMBL; AY171209; AAO16357.1; -; Genomic_DNA.
DR EMBL; AY171210; AAO16359.1; -; Genomic_DNA.
DR EMBL; AY171211; AAO16361.1; -; Genomic_DNA.
DR EMBL; AY171212; AAO16363.1; -; Genomic_DNA.
DR EMBL; AY171213; AAO16365.1; -; Genomic_DNA.
DR EMBL; AY171214; AAO16367.1; -; Genomic_DNA.
DR EMBL; AY171215; AAO16369.1; -; Genomic_DNA.
DR EMBL; AY171216; AAO16371.1; -; Genomic_DNA.
DR EMBL; AY171217; AAO16373.1; -; Genomic_DNA.
DR EMBL; AY171218; AAO16375.1; -; Genomic_DNA.
DR EMBL; AY171219; AAO16377.1; -; Genomic_DNA.
DR EMBL; AY171220; AAO16379.1; -; Genomic_DNA.
DR EMBL; AY171221; AAO16381.1; -; Genomic_DNA.
DR EMBL; AY171222; AAO16383.1; -; Genomic_DNA.
DR EMBL; X54252; CAA38161.1; -; Genomic_DNA.
DR PIR; S26036; S26036.
DR RefSeq; NP_006963.1; NC_001328.1.
DR AlphaFoldDB; P24895; -.
DR SMR; P24895; -.
DR STRING; 6239.MTCE.34; -.
DR EPD; P24895; -.
DR PaxDb; P24895; -.
DR EnsemblMetazoa; MTCE.34.1; MTCE.34.1; WBGene00010966.
DR GeneID; 2565696; -.
DR KEGG; cel:ND3; -.
DR CTD; 4537; -.
DR WormBase; MTCE.34; CE35352; WBGene00010966; nduo-3.
DR eggNOG; KOG4662; Eukaryota.
DR HOGENOM; CLU_2388808_0_0_1; -.
DR InParanoid; P24895; -.
DR OrthoDB; 1605459at2759; -.
DR PhylomeDB; P24895; -.
DR PRO; PR:P24895; -.
DR Proteomes; UP000001940; Mitochondrion.
DR Bgee; WBGene00010966; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:WormBase.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..111
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117721"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 111 AA; 13005 MW; 60C96B55D4D2B2C3 CRC64;
MLVLLMVLVF TLVLLFAFYL INFLLSIKDM GKNKISAFEC GFVSVGKIQN SFSIHFFIMM
LMFVIFDLEI VMFLGILVSD LSSYISFLMM FIFILGGFYM EWWYGKLVWV I
