ID   NU3M_CANAL              Reviewed;         129 AA.
AC   Q9B8D1;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=NAD3; OrderedLocusNames=CM_00320W {ECO:0000312|CGD:CAL0000179355};
GN   ORFNames=CaalfMp10;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=11208783; DOI=10.1128/jb.183.3.865-872.2001;
RA   Anderson J.B., Wickens C., Khan M., Cowen L.E., Federspiel N.A., Jones T.,
RA   Kohn L.M.;
RT   "Infrequent genetic exchange and recombination in the mitochondrial genome
RT   of Candida albicans.";
RL   J. Bacteriol. 183:865-872(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; AF285261; AAG59595.2; -; Genomic_DNA.
DR   RefSeq; NP_075038.2; NC_002653.1.
DR   AlphaFoldDB; Q9B8D1; -.
DR   SMR; Q9B8D1; -.
DR   STRING; 237561.Q9B8D1; -.
DR   GeneID; 802552; -.
DR   KEGG; cal:CaalfMp10; -.
DR   CGD; CAL0000179355; NAD3.
DR   VEuPathDB; FungiDB:CM_00320W; -.
DR   InParanoid; Q9B8D1; -.
DR   Proteomes; UP000000559; Mitochondrion.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:CGD.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:CGD.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:CGD.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..129
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000356877"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   129 AA;  14706 MW;  E63AB6825AD79F8B CRC64;
     MFTFYMYLAP IVAGVLIGLN WLLAKSNPNI DKAGPFECGF TSYQQSRAAF SVAFILVAIL
     FLPFDLEISS ILPYVTSAYN NGLYGLIILI IFLMMLVIAF ILEIQLRVLK IERSYDKDRS
     DSNYYDHEI