NU3M_CHICK
ID NU3M_CHICK Reviewed; 116 AA.
AC P18938;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3;
OS Gallus gallus (Chicken).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=2329578; DOI=10.1016/0022-2836(90)90225-b;
RA Desjardins P., Morais R.;
RT "Sequence and gene organization of the chicken mitochondrial genome. A
RT novel gene order in higher vertebrates.";
RL J. Mol. Biol. 212:599-634(1990).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03898}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; X52392; CAA36632.1; -; Genomic_DNA.
DR PIR; S10194; S10194.
DR RefSeq; NP_006922.1; NC_001323.1.
DR AlphaFoldDB; P18938; -.
DR SMR; P18938; -.
DR STRING; 9031.ENSGALP00000034619; -.
DR PaxDb; P18938; -.
DR Ensembl; ENSGALT00000049217; ENSGALP00000043487; ENSGALG00000030436.
DR VEuPathDB; HostDB:geneid_63549491; -.
DR eggNOG; KOG4662; Eukaryota.
DR GeneTree; ENSGT00390000011605; -.
DR HOGENOM; CLU_119549_3_1_1; -.
DR InParanoid; P18938; -.
DR OMA; RFPVKYY; -.
DR OrthoDB; 1605459at2759; -.
DR PhylomeDB; P18938; -.
DR TreeFam; TF343336; -.
DR Reactome; R-GGA-611105; Respiratory electron transport.
DR Reactome; R-GGA-6799198; Complex I biogenesis.
DR PRO; PR:P18938; -.
DR Proteomes; UP000000539; Mitochondrion.
DR Bgee; ENSGALG00000030436; Expressed in heart and 13 other tissues.
DR ExpressionAtlas; P18938; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..116
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117727"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 116 AA; 13121 MW; 10CAEE764F86D72B CRC64;
MNTLTFMLSL SFLLSAALTT MNFWLAQMAP DTEKLSPYEC GFDPLGSARL PFSIRFFLVA
ILFLLFDLEI ALLLPLPWAI QLAHPMMTLT WATTIIALLT FGLIYEWTQG GLEWAE
