ID   NU3M_DANRE              Reviewed;         116 AA.
AC   Q9MIY3;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=mt-nd3; Synonyms=mtnd3, nd3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=11691861; DOI=10.1101/gr.156801;
RA   Broughton R.E., Milam J.E., Roe B.A.;
RT   "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome
RT   and evolutionary patterns in vertebrate mitochondrial DNA.";
RL   Genome Res. 11:1958-1967(2001).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity of complex I.
CC       {ECO:0000250|UniProtKB:P03897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03897};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits.
CC       {ECO:0000250|UniProtKB:P03898}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; AC024175; AAF74304.1; -; Genomic_DNA.
DR   RefSeq; NP_059338.1; NC_002333.2.
DR   AlphaFoldDB; Q9MIY3; -.
DR   SMR; Q9MIY3; -.
DR   STRING; 7955.ENSDARP00000087876; -.
DR   PaxDb; Q9MIY3; -.
DR   Ensembl; ENSDART00000093615; ENSDARP00000087876; ENSDARG00000063914.
DR   GeneID; 140533; -.
DR   KEGG; dre:140533; -.
DR   CTD; 4537; -.
DR   ZFIN; ZDB-GENE-011205-9; mt-nd3.
DR   eggNOG; KOG4662; Eukaryota.
DR   GeneTree; ENSGT00390000011605; -.
DR   HOGENOM; CLU_119549_3_1_1; -.
DR   InParanoid; Q9MIY3; -.
DR   OMA; RFPVKYY; -.
DR   OrthoDB; 1605459at2759; -.
DR   PhylomeDB; Q9MIY3; -.
DR   TreeFam; TF343336; -.
DR   Reactome; R-DRE-611105; Respiratory electron transport.
DR   Reactome; R-DRE-6799198; Complex I biogenesis.
DR   PRO; PR:Q9MIY3; -.
DR   Proteomes; UP000000437; Mitochondrion MT.
DR   Proteomes; UP000814640; Mitochondrion.
DR   Bgee; ENSDARG00000063914; Expressed in brain and 21 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..116
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117720"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   116 AA;  13111 MW;  54128E3477BFC001 CRC64;
     MNLFATILII MTTLSLVLAL VSFWLPQMNS DTEKLSPYEC GFDPLGSARL PFSLRFFLVA
     VLFPLFDLEI ALLLPLPWGD QLNNPMETLF WAMTVLILLT LGLAYEWAQG GLEWAE