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NU3M_DROME
ID   NU3M_DROME              Reviewed;         117 AA.
AC   P18930; Q7HM99;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=mt:ND3; Synonyms=ND3;
OS   Drosophila melanogaster (Fruit fly).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bretagne;
RX   PubMed=3130291; DOI=10.1093/genetics/118.4.649;
RA   Garesse R.;
RT   "Drosophila melanogaster mitochondrial DNA: gene organization and
RT   evolutionary considerations.";
RL   Genetics 118:649-663(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Oregon-R, and Zimbabwe 53;
RX   PubMed=10903372; DOI=10.1007/s002390010066;
RA   Ballard J.W.O.;
RT   "Comparative genomics of mitochondrial DNA in members of the Drosophila
RT   melanogaster subgroup.";
RL   J. Mol. Evol. 51:48-63(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Paris;
RX   PubMed=11298822; DOI=10.1046/j.1365-2540.2001.00814.x;
RA   Azou Y., Bregliano J.C.;
RT   "I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of
RT   the mitochondrial DNA in reactive strains exhibiting different potentials
RT   for I factor transposition.";
RL   Heredity 86:110-116(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8825764; DOI=10.1111/j.1365-2583.1995.tb00032.x;
RA   Lewis D.L., Farr C.L., Kaguni L.S.;
RT   "Drosophila melanogaster mitochondrial DNA: completion of the nucleotide
RT   sequence and evolutionary comparisons.";
RL   Insect Mol. Biol. 4:263-278(1995).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RA   Wan K., Celniker S.;
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
RC   STRAIN=Oregon-R;
RX   PubMed=6304652; DOI=10.1093/nar/11.8.2411;
RA   Clary D.O., Wahleithner J.A., Wolstenholme D.R.;
RT   "Transfer RNA genes in Drosophila mitochondrial DNA: related 5' flanking
RT   sequences and comparisons to mammalian mitochondrial tRNA genes.";
RL   Nucleic Acids Res. 11:2411-2425(1983).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; M37275; AAA69709.1; -; Genomic_DNA.
DR   EMBL; AF200828; AAF77232.1; -; Genomic_DNA.
DR   EMBL; AF200829; AAF77244.1; -; Genomic_DNA.
DR   EMBL; AJ400907; CAB91057.1; -; Genomic_DNA.
DR   EMBL; U37541; AAC47817.1; -; Genomic_DNA.
DR   EMBL; KJ947872; AIC64010.1; -; Genomic_DNA.
DR   EMBL; J01404; AAB59244.1; -; Genomic_DNA.
DR   PIR; S01185; S01185.
DR   RefSeq; YP_009047272.1; NC_024511.2.
DR   AlphaFoldDB; P18930; -.
DR   SMR; P18930; -.
DR   STRING; 7227.FBpp0100181; -.
DR   PaxDb; P18930; -.
DR   EnsemblMetazoa; FBtr0100870; FBpp0100181; FBgn0013681.
DR   GeneID; 19893542; -.
DR   KEGG; dme:Dmel_CG34076; -.
DR   CTD; 4537; -.
DR   FlyBase; FBgn0013681; mt:ND3.
DR   VEuPathDB; VectorBase:FBgn0013681; -.
DR   eggNOG; KOG4662; Eukaryota.
DR   GeneTree; ENSGT00390000011605; -.
DR   HOGENOM; CLU_119549_3_1_1; -.
DR   InParanoid; P18930; -.
DR   Reactome; R-DME-611105; Respiratory electron transport.
DR   Reactome; R-DME-6799198; Complex I biogenesis.
DR   BioGRID-ORCS; 19893542; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 19893542; -.
DR   PRO; PR:P18930; -.
DR   Proteomes; UP000000803; Mitochondrion.
DR   Bgee; FBgn0013681; Expressed in Malpighian tubule and 15 other tissues.
DR   ExpressionAtlas; P18930; baseline and differential.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:FlyBase.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; NAD; Reference proteome;
KW   Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..117
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117736"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   117 AA;  13564 MW;  6DB7AFDA72924892 CRC64;
     MFSIIFIALL ILLITTIVMF LASILSKKAL IDREKSSPFE CGFDPKSSSR LPFSLRFFLI
     TIIFLIFDVE IALILPMIII MKYSNIMIWT ITSIIFILIL LIGLYHEWNQ GMLNWSN
 
 
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