ID   NU3M_HELAN              Reviewed;         118 AA.
AC   P60159; P18903; Q96032;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE            EC=7.1.1.2;
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=ND3; Synonyms=NAD3;
OS   Helianthus annuus (Common sunflower).
OG   Mitochondrion.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND RNA EDITING.
RC   STRAIN=cv. Gloriasol; TISSUE=Etiolated shoot;
RX   PubMed=8676875; DOI=10.1007/bf02172523;
RA   Perrotta G., Regina T.M.R., Ceci L.R., Quagliariello C.C.;
RT   "Conservation of the organization of the mitochondrial nad3 and rps12 genes
RT   in evolutionarily distant angiosperms.";
RL   Mol. Gen. Genet. 251:326-337(1996).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- RNA EDITING: Modified_positions=2 {ECO:0000269|PubMed:8676875}, 15
CC       {ECO:0000269|PubMed:8676875}, 21 {ECO:0000269|PubMed:8676875}, 27
CC       {ECO:0000269|PubMed:8676875}, 46 {ECO:0000269|PubMed:8676875}, 49
CC       {ECO:0000269|PubMed:8676875}, 64 {ECO:0000269|PubMed:8676875}, 70
CC       {ECO:0000269|PubMed:8676875}, 72 {ECO:0000269|PubMed:8676875}, 77
CC       {ECO:0000269|PubMed:8676875}, 83 {ECO:0000269|PubMed:8676875}, 84
CC       {ECO:0000269|PubMed:8676875}, 92 {ECO:0000269|PubMed:8676875}, 106
CC       {ECO:0000269|PubMed:8676875}, 115 {ECO:0000269|PubMed:8676875}, 117
CC       {ECO:0000269|PubMed:8676875};
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; Z49775; CAA89856.1; -; mRNA.
DR   PIR; S71077; S71077.
DR   AlphaFoldDB; P60159; -.
DR   SMR; P60159; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   HAMAP; MF_01394; NDH1_NuoA; 1.
DR   InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW   RNA editing; Translocase; Transmembrane; Transmembrane helix; Transport;
KW   Ubiquinone.
FT   CHAIN           1..118
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117749"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   118 AA;  13725 MW;  EDB9759B8C2488CC CRC64;
     MLEFAPICIY LVISLLVSLI LLGVPFLFAS NSSTYPEKLS AYECGFDPFG DARSRFDIRF
     YLVSILFIIF DLEVTFFFPW AVSLNKIDLF GFWSMMAFLL ILTIGFLYEW KRGALDWE