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NU3M_HIPAM
ID   NU3M_HIPAM              Reviewed;         115 AA.
AC   Q9ZZY4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS   Hippopotamus amphibius (Hippopotamus).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Ancodonta;
OC   Hippopotamidae; Hippopotamus.
OX   NCBI_TaxID=9833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9881471; DOI=10.1098/rspb.1998.0567;
RA   Ursing B.M., Arnason U.;
RT   "Analyses of mitochondrial genomes strongly support a hippopotamus-whale
RT   clade.";
RL   Proc. R. Soc. B 265:2251-2255(1998).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity of complex I.
CC       {ECO:0000250|UniProtKB:P03897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03897};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits (By similarity).
CC       Interacts with TMEM186 (By similarity). Interacts with TMEM242 (By
CC       similarity). {ECO:0000250|UniProtKB:P03897}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; AJ010957; CAA09435.1; -; Genomic_DNA.
DR   RefSeq; NP_008797.1; NC_000889.1.
DR   AlphaFoldDB; Q9ZZY4; -.
DR   SMR; Q9ZZY4; -.
DR   GeneID; 808676; -.
DR   CTD; 4537; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..115
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117750"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  12920 MW;  8669772D5B604030 CRC64;
     MNLVMALLTN TALASLLVLI AFWLPQLNSY AEKTSPYECG FDPMGSARLP FSMKFFLVAI
     TFLLFDLEVA LLLPLPWATQ TTNLKTMLIM ALTLISLLAI SLAYEWTQKG LEWTE
 
 
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