ID   NU3M_HORSE              Reviewed;         115 AA.
AC   P48654;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS   Equus caballus (Horse).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000312|Proteomes:UP000002281};
RX   PubMed=7958969; DOI=10.1016/0378-1119(94)90713-7;
RA   Xu X., Arnason U.;
RT   "The complete mitochondrial DNA sequence of the horse, Equus caballus:
RT   extensive heteroplasmy of the control region.";
RL   Gene 148:357-362(1994).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity of complex I.
CC       {ECO:0000250|UniProtKB:P03897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03897};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits. Interacts with TMEM186.
CC       Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; X79547; CAA56086.1; -; Genomic_DNA.
DR   PIR; T11864; T11864.
DR   RefSeq; NP_007167.1; NC_001640.1.
DR   AlphaFoldDB; P48654; -.
DR   SMR; P48654; -.
DR   STRING; 9796.ENSECAP00000023102; -.
DR   PaxDb; P48654; -.
DR   Ensembl; ENSECAT00000029835; ENSECAP00000023102; ENSECAG00000027695.
DR   GeneID; 807855; -.
DR   KEGG; ecb:807855; -.
DR   CTD; 4537; -.
DR   VGNC; VGNC:59018; MT-ND3.
DR   GeneTree; ENSGT00390000011605; -.
DR   HOGENOM; CLU_119549_3_1_1; -.
DR   InParanoid; P48654; -.
DR   OMA; RFPVKYY; -.
DR   OrthoDB; 1605459at2759; -.
DR   Proteomes; UP000002281; Mitochondrion.
DR   Bgee; ENSECAG00000027695; Expressed in triceps brachii and 23 other tissues.
DR   ExpressionAtlas; P48654; baseline.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW   Transmembrane helix; Transport; Ubiquinone.
FT   CHAIN           1..115
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117751"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13017 MW;  4F5858381F0C8372 CRC64;
     MNLMLTLLTN TLLASLLVLI AFWLPQLNIY AEKTSPYECG FDPMGSARLP FSMKFFLVAI
     TFLLFDLEIA LLLPLPWASQ TTNLNTMLIM ALVLISLLAI SLAYEWTQKG LEWTE