NU3M_LEMCA
ID NU3M_LEMCA Reviewed; 115 AA.
AC Q8HQB1; Q94Y88;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS Lemur catta (Ring-tailed lemur).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Lemuridae; Lemur.
OX NCBI_TaxID=9447;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate JP3;
RX PubMed=12393004; DOI=10.1016/s0047-2484(02)90587-7;
RA Pastorini J., Forstner M.R., Martin R.D.;
RT "Phylogenetic relationships among Lemuridae (Primates): evidence from
RT mtDNA.";
RL J. Hum. Evol. 43:463-478(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate JP3, and Isolate JP52;
RX PubMed=12719521; DOI=10.1073/pnas.1031673100;
RA Pastorini J., Thalmann U., Martin R.D.;
RT "A molecular approach to comparative phylogeography of extant Malagasy
RT lemurs.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:5879-5884(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12034869; DOI=10.1073/pnas.102164299;
RA Arnason U., Adegoke J.A., Bodin K., Born E.W., Esa Y.B., Gullberg A.,
RA Nilsson M., Short R.V., Xu X., Janke A.;
RT "Mammalian mitogenomic relationships and the root of the eutherian tree.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:8151-8156(2002).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity of complex I.
CC {ECO:0000250|UniProtKB:P03897}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03897};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits. Interacts with TMEM186.
CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR EMBL; AF053684; AAL18017.1; -; Genomic_DNA.
DR EMBL; AF224569; AAN64754.1; -; Genomic_DNA.
DR EMBL; AF224570; AAN64758.1; -; Genomic_DNA.
DR EMBL; AJ421451; CAD13428.1; -; Genomic_DNA.
DR RefSeq; NP_659295.1; NC_004025.1.
DR AlphaFoldDB; Q8HQB1; -.
DR SMR; Q8HQB1; -.
DR GeneID; 804957; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR Gene3D; 1.20.58.1610; -; 1.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW Transport; Ubiquinone.
FT CHAIN 1..115
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117756"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 12
FT /note="T -> I (in strain: Isolate JP52)"
SQ SEQUENCE 115 AA; 12983 MW; 038D7A9D31F4372D CRC64;
MNLPLALTTS ITLTLLLVTI AFWLPQLNVY TEKYSPYECG FDPMGSARLP FSMKFFLVAI
TFLLFDLEIA LLLPLPWASQ TNNLKLMLTV ALVLITILAA GLAYEWLQKG LEWVE