NU3M_MAIZE
ID NU3M_MAIZE Reviewed; 118 AA.
AC P16265;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 3.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 3;
GN Name=ND3; Synonyms=NAD3;
OS Zea mays (Maize).
OG Mitochondrion.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. WF9-N;
RX PubMed=2853827; DOI=10.1007/bf00331312;
RA Gualberto J.M., Wintz H., Weil J.-H., Grienenberger J.-M.;
RT "The genes coding for subunit 3 of NADH dehydrogenase and for ribosomal
RT protein S12 are present in the wheat and maize mitochondrial genomes and
RT are co-transcribed.";
RL Mol. Gen. Genet. 215:118-127(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RC STRAIN=cv. Black Mexican Sweet;
RX PubMed=8662195; DOI=10.1007/bf02426960;
RA Grosskopf D., Mulligan R.M.;
RT "Developmental- and tissue-specificity of RNA editing in mitochondria of
RT suspension-cultured maize cells and seedlings.";
RL Curr. Genet. 29:556-563(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=2 {ECO:0000269|PubMed:8662195}, 15
CC {ECO:0000269|PubMed:8662195}, 21 {ECO:0000269|PubMed:8662195}, 27
CC {ECO:0000269|PubMed:8662195}, 46 {ECO:0000269|PubMed:8662195}, 49
CC {ECO:0000269|PubMed:8662195}, 62 {ECO:0000269|PubMed:8662195}, 64
CC {ECO:0000269|PubMed:8662195}, 70 {ECO:0000269|PubMed:8662195}, 72
CC {ECO:0000269|PubMed:8662195}, 77 {ECO:0000269|PubMed:8662195}, 83
CC {ECO:0000269|PubMed:8662195}, 84 {ECO:0000269|PubMed:8662195}, 92
CC {ECO:0000269|PubMed:8662195}, 103 {ECO:0000269|PubMed:8662195}, 115
CC {ECO:0000269|PubMed:8662195}, 117 {ECO:0000269|PubMed:8662195};
CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X14709; CAA32833.1; ALT_SEQ; Genomic_DNA.
DR PIR; S70025; DNZMU3.
DR AlphaFoldDB; P16265; -.
DR SMR; P16265; -.
DR PRIDE; P16265; -.
DR MaizeGDB; 69626; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.58.1610; -; 1.
DR HAMAP; MF_01394; NDH1_NuoA; 1.
DR InterPro; IPR023043; NAD(P)H_OxRDtase_bac/plastid.
DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR PANTHER; PTHR11058; PTHR11058; 1.
DR Pfam; PF00507; Oxidored_q4; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain;
KW RNA editing; Translocase; Transmembrane; Transmembrane helix; Transport;
KW Ubiquinone.
FT CHAIN 1..118
FT /note="NADH-ubiquinone oxidoreductase chain 3"
FT /id="PRO_0000117761"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 13711 MW; 4C59759B9C2588DA CRC64;
MLEFAPICIY LVISLLVSLI LLGVPFLFAS NSSTYPEKLS AYECGFDPFG DARSRFDIRF
YLVSILFIIF DLEVTFFFPW AVSLNKIDLF GFWSMMAFLL ILFIGSLYEW KRGALDWE
